摘要
目的 :考察羟基磷灰石陶瓷为药物载体、蜂蜡为阻滞剂制备的不同浓度蜂蜡包裹的米托蒽醌缓释复合人工骨 (DHAQ -PHA -WAX)与未包裹蜂蜡的米托蒽醌人工骨 (DHAQ -PHA)的体外释药规律。方法 :可见分光光度法于 6 6 0nm处测定包裹与未包裹蜂蜡的米托蒽醌 -人工骨每天的释药量。结果 :DHAQ -PHA与DHAQ -PHA -WAX的溶出速率有显著差异 (P <0 0 5)。结论 :DHAQ -PHA -WAX可有效地控制药物的释放。
OBJECTIVE:To investigate the drug-releasing regularity in vitro of variable concentration mitoxantrone,which wax in a matoxantrone hydroxylapatite ceramic composite encapsulated with wax (DHAQ-PHA-WAX) and DHAQ-PHA without the wax.hydroxylapatite ceramic was used as drug carrier and wax as inhibitor.METHODS:The released drug concentration per-day was determined by visible spectrometry at λ =660nm.RESULTS:There was a significant difference ( P <0 05) between DHAQ-PHA dissolution velocity and DHAQ-PHA-WAX.CONCLUTION:Releasing of DHAQ could be controlled with DHAQ-PHA-WAX.
出处
《药学实践杂志》
CAS
1999年第5期298-299,共2页
Journal of Pharmaceutical Practice
关键词
羟基磷灰石
复合人工骨
蜂蜡
米托蒽醌
药物载体
hydroxylapatite ceramic composite,wax,mitoxantrone,rate of drug-releasing
