摘要
结直肠癌前病变从管状腺瘤轻度、中度、重度不典型增生,细胞增殖和凋亡能力不断增加,凋亡与增殖比例渐增高;绒毛状腺瘤与管状腺瘤相比凋亡能力下降,体积增大呈现膨胀性生长;而重度不典型结直肠腺瘤增殖能力显著高于原位癌,显示它们是两种不同的病变。随着结直肠癌分化程度降低,增殖能力下降,凋亡受抑,易浸润转移。APC、survivin、COX基因及相关Wnt信号通路等影响细胞凋亡与增殖,其双向调节作用可能具有特别重要的生物学意义。
The proportion of proliferation and apoptosis increased progressively with different degrees of dysplasia in tubular adenomas of the colorectum,which parallelled the tendency of both of them.The villous adenomas with significantly lower AI（apoptosis index）,when compared with tubular adenomas,increases in volumn showing an expansive growth.Abnormal proliferation is more frequent in severe atypia colorectal adenomas than in carcinoma in situ,as severe dysplasia and carcinoma in situ are two dissimilar morphological entities with dissimilar proliferative characters.The proliferation lowers along with the lowering of adenocarcinomas differentiation degree and the apoptosis is inhibited.Besides,the slow proliferation is a biological feature correlated with invasion and metastasis in colorectal cancer.The two-way modulation of APC,survivin,COX gene and Wnt-signalling pathway may have great biological significance.
出处
《医学综述》
2011年第9期1321-1323,共3页
Medical Recapitulate
基金
云南省科技厅昆明医学院应用基础研究联合基金(2008CD004R)
关键词
结直肠癌
增殖
凋亡
浸润
转移
Colorectal cancer
Proliferation
Apoptosis
Invasion
Metastasis
