摘要
目的:观察滋阴清热法为主治疗咳嗽变异性哮喘(cough variant asthma,CVA)阴虚内热证的有效性及安全性。方法:随机、平行对照临床试验设计,选择符合研究标准的咳嗽变异性哮喘患者70例,治疗组34例、对照组34例(两组各脱落1例)。治疗组给予滋阴清热法为主组方的汤剂,对照组给予茶碱缓释胶囊治疗,100mg,口服,每12h 1次。两组均以4周为1个疗程。分别在治疗前后观察患者咳嗽、咽痒、咯痰、气急等症状变化。结果:治疗4周后,治疗组患者咳嗽、咽痒、咯痰症状明显轻于对照组,两组间差异具有统计学意义(P<0.05)。咳嗽症状疗效比较:治疗组与对照组有效率分别为91.2%和79.4%,两组间差异具有统计学意义(P<0.05)。中医证候综合疗效比较:治疗组与对照组有效率分别为85.3%和70.6%,两组间差异具有统计学意义(P<0.05)。两组在用药期间均未发生不良反应。结论:滋阴清热法为主治疗咳嗽变异性哮喘安全有效。
Objective： To evaluate the efficacy and safety of Zi Yin Qing Re therapy in treating cough variant asthma （CAV） due to yin asthenia and internal heat. Methods： A randomized controlled trial was conducted. 70 CVA patientswere randomly divided into control group and treatment group, the 34 patients （ 1 dropped out） in the treatment group were treated with Chinese herbs of Zi Yin Qing Re therapy, and the 34 patients （ 1 dropped out） in the control group were treated with theophylline susta/ned- release capsules, lOOrag, 1 per 12 hours, treatment course lasted for 4 weeks. The symptoms change of cough, throat itching, expectoration and shortness of breath were observed in patients before and after treatment. Results： Four weeks after taking the medicine, the improvement of patients＇symptoms, including cough, throat itching and expectoration in the treatment group were more obvious than that in the control group （ P 〈 0.05 ）. The cough effective rates were 91.2 % in treatment group and 79.4 % in control group （P 〈0.05）. The TCM syndrome total effective rates were 85.3% in treatment group and 70.6% in control group （ P 〈0.05 ）. No significant side effects were noted in both groups. Conclusion： Zi Yin Qing Re therapy is effective and safe in treating cough variant asthma due to yin asthenia and internal heat.
出处
《中华中医药学刊》
CAS
2011年第5期1041-1043,共3页
Chinese Archives of Traditional Chinese Medicine
基金
首都医学科技发展基金资助项目(SF-2007-Ⅱ-05)
关键词
咳嗽变异性哮喘
滋阴清热法
随机对照试验
中医药疗法
cough variant asthma
Zi Yin Qing Re therapy
randomized controlled trial
Traditional Chinese Medicine
