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应用差异蛋白质组学的方法分析左氧氟沙星对肺炎链球菌D39的作用 被引量：1

The effect of Levofloxacin on Streptococcus pneumoniae D39 revealed by comparative proteomics
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摘要 应用差异蛋白质组学的方法,对肺炎链球菌D39在左氧氟沙星作用下蛋白质表达水平的变化进行了研究,利用质谱技术共鉴定到23个差异蛋白质。这些蛋白质主要参与DNA的复制、转录以及蛋白质的翻译过程,为深入了解抗生素的作用机理以及细菌的耐药机制提供重要理论基础。 The protein expression levels of Streptococcus pneumoniae D39 upon Levofloxacin treat-ment were studied using comparative proteomics method.In total,23 differentially expressed proteins were identified via mass spectrometry.These proteins mainly involved in the DNA replication,tran-scription and protein translation.This study provides important information to the molecular mecha-nism of antibiotics actions and the drug resistance of bacteria.
作者 孙正华 阳小燕 贺翔 孙雪松
机构地区 暨南大学生命与健康工程研究院
出处 《微生物学通报》 CAS CSCD 北大核心 2011年第5期758-764,共7页 Microbiology China
基金 国家自然科学基金项目(No.31000373) 广东省自然科学基金项目(No.10451063201005247) 暨南大学科研培育与创新基金项目(No.21609301)
关键词 差异蛋白质组学 肺炎链球菌 左氧氟沙星 Comparative proteomics Streptococcus pneumoniae Levofloxacin
分类号 R96 [医药卫生—药理学]
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参考文献23

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微生物学通报
2011年 第5期

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