摘要
目的研究曲美他嗪对高血压心脏病患者的治疗作用。方法入选2006年4月至2008年11月在德阳市人民医院诊断为高血压心脏病患者84例。以入院顺序单双号法随机分为常规治疗组(对照组)和加用曲美他嗪组,每组各42例,超声心动图检查并记录入选时及治疗12、24个月时左室射血分数(LVEF)及左心室质量指数(LVMI)。结果 12个月时,曲美他嗪组患者LVEF较入选时明显增加(P=0.0389),24个月时进一步改善(P=0.0093)。对照组患者LVEF于12、24个月时略增加,但差异无统计学意义(P=0.5426)。12、24个月时LVMI于对照组有降低趋势,但均无统计学意义。12个月时曲美他嗪组LVMI明显减低(P=0.0421),24个月时减低更明显(P=0.0086)。两组间比较,12个月时曲美他嗪组LVEF明显高于对照组(P=0.0443),24个月时差异更显著(P=0.0085);12个月时曲美他嗪组LVMI低于对照组(P=0.0392),24个月时差异更明显(P=0.0053)。结论在常规降压治疗的基础上加用曲美他嗪,有助于进一步改善左心室收缩功能及逆转左心室肥厚。
Objective To study the effects of trimetazidine on the left ventricular function of patients with hypertensive heart disease（HHD）.Methods 84 patients with HHD were enrolled in the people＇s hospital of Deyang from April 2006 to November 2008.They were randomly assigned to either conventional treatment group（control group） or trimetazidine in addition to conventional treatment group（trimetazidine group）,42 patients per group.Left ventricular ejection fraction（LVEF） and left ventricular mass index（LVMI）were determined by echocardiography at baseline and 12,24 months after treatment.Results Compared with baseline,LVEF in trimetazidine group increased significantly at 12 months（P=0.0389） and increased more notably at 24 months（P=0.0093）.The increment of LVEF in control group was not statistically significant at 12 and 24 months（P=0.5426）.Compared with baseline,LVMI in control group was lightly decreased but was not significant at 12 and 24 months,LVMI in trimetazidine group was significantly decreased at 12 months（P=0.0421） and more markedly decreased at 24 months（P=0.0086）.The increment of LVEF in trimetazidine group was significantly higher than that in control group at 12 months（P=0.0443） and the difference was more notable at 24 months（P=0.0085）.The decrease of LVMI between the two groups was significant at 12 months（P=0.0392） and more marked at 24 months（P=0.0053）.Conclusions Trimetazidine in addition to conventional therapy was associated with the significant improvement of left ventricular function and the reversal of left ventricular hypertrophy.
出处
《中国医药指南》
2011年第13期201-203,共3页
Guide of China Medicine
关键词
曲美他嗪
高血压
心室功能
Ttrimetazidine
Hypertension
Ventricular function
Left
