摘要
目的:探讨右肺动脉神经节丛(RPVGP)消融对胆碱能及儿茶酚胺诱发房颤的影响。方法:20只犬麻醉开胸后,暴露RPVGP,分别在消融RPVGP前后,经股静脉静滴乙酰胆碱(ACh)及儿茶酚胺。测量房颤诱发率及两类递质诱发房颤的阈浓度。结果:RPVGP消融前,静滴Ach和异丙基肾上腺素(IPA)及肾上腺素(EPI)(1～100μmol/l)均可诱发AF,诱发率100%。Ach、IPA和EPI的诱发阈浓度分别为2.6±0.3μmol/l,3.3±0.2μmol/l,5.6±0.2μmol/l。RPVGP消融后,Ach及儿茶酚胺的AF诱发率分别降至10%及35%,且三种递质的诱发阈浓度分别提高至2.6±0.3μmol/l、22.5±2.4μmol/l和26.±2.6μmol/(lP<0.05)。结论:消融RPVGP使乙酰胆碱和儿茶酚胺诱发房颤的阈浓度增高,并降低此二类介质的房颤诱发率。
Objective： To investigate the effects of right pulmonary artery ganglionated plexi（RPVGP） ablation on cholinergic and beta-adrenergic mediated atrial fibrillation（AF）.Methods： 20 dogs were chosen in this study,and the chest was opened through the left fourth intercostals,then the RPVGP was exposed.Catecholamines and acetylcholine（ACh） were perfused through the femarol vein to induce AF.AF inducing rate and the threshold concentration were measured before and after RPVGP ablation respectively.Results： ACh,isoprenalin（IPA） and adrenaline（EPI） could induce AF before RPVGP ablation,AF inducing rate was 100%.The threshold concentration of ACh,isoprenalin（IPA） and adrenaline（EPI） was 2.6±0.3μmol/l,3.3±0.2 μmol/l,5.6±0.2 μmol/l respectively.However,after RPVGP ablation,Ach and catecholamines mediated AF inducing rate decreased significantly to 10% and 35%（P0.05）.And the threshold concentration increased significantly to 2.6±0.3μmol/l,22.5±2.4 and 26.6±2.6μmol/l respectively（P0.05）.Conclusions： Catheter ablation of RPVGP increased the threshold concentration of Ach and catecholamines in AF inducing,and decreased the inducing rate of AF both mediated.
出处
《现代生物医学进展》
CAS
2011年第8期1461-1463,共3页
Progress in Modern Biomedicine
基金
军队"十一五"医药卫生科研基金资助项目(01MB126)
关键词
自主神经
肾上腺素能
胆碱能
神经节丛
阵发性房颤
Autonomic system
Adrenergic
Cholinergic
Ganglionated plexi
Paroxysmal atrial fibrillation
