摘要
以酚妥拉明及新斯的明为工具药， 从鼠侧脑室注入盐酸乌苏里藜芦碱（Ｖｅｒａ － Ｕ， ３μｇ·ｋｇ－ １） 研究其中枢降压机制。实验表明： 侧脑室注入Ｖｅｒａ － Ｕ可显著降低肾性高血压大鼠的血压， 其降压作用可被侧脑室预先注入的α受体阻断剂酚妥拉明完全阻断； 侧脑室注入胆碱酯酶抑制剂后， 肾性高血压大鼠血压明显升高， 新斯的明升高血压作用不受预先注入的Ｖｅｒａ－ Ｕ 的影响。结果提示： Ｖｅｒａ － Ｕ侧脑室注射对肾性高血压大鼠具有迅速而显著的降压作用； 其中枢机制在降压过程中发挥重要作用： 中枢α受体参与介导了Ｖｅｒａ － Ｕ 对肾性高血压大鼠的降压作用。
To stndy the mechanism of vera-U hypotensive effect,this drug and the tool drugs,phentolamine and niostigmine were injected introcerebroventrically(i.c.v.) in renal hypertensive rats(RHR).Vera-U(i.c.v) caused a remarkable decrease of mean arterial pressure in RHR.Pretreatment with phentolamine completely abolished the hypotensive effect of Vera-U;pretreatment with Vera-U(i.c.v.)caused no remarkable change in the pressure effect of niostigmine.The results suggested that Vera-U(i.c.v.)can produce immediate and significant hypotensive effects in RHR,central mechanism plays an important role in this process and central α-receptor mediats the hypotensive effect of Vera-U in RHR.
出处
《大连医科大学学报》
CAS
1999年第3期163-165,共3页
Journal of Dalian Medical University
关键词
降压机制
肾性高血压
藜芦
Vera-U
药理
blood pressure hypotensive mechanism
cerebroventricle
central system
