摘要
目的:观察利培酮和阿立哌唑治疗老年痴呆精神行为症状的疗效和安全性。方法:将57例老年痴呆精神行为症状的患者随机分为两组,采用利培酮和阿立哌唑治疗,疗程12周。分别于治疗前及治疗4、8、12周末应用痴呆病理行为评定量表(BEHAVE-AD)评定疗效和副反应量表(TESS)评定不良反应。结果:两组患者治疗后BEHAVE-AD评分显著下降(P<0.01),两组患者之间治疗前后BEHANE-AD的减分值差异无显著性(P(0.05),不良反应之间差异无显著性(P(0.05),有效率分别为82.76%和78.57%。结论:利培酮和阿立哌唑两种新型抗精神病药治疗老年痴呆精神行为症状疗效均确切,起效快、不良反应少。
Objective：To investigate the clinical efficacy and side effects of Risperidone and Aripiprazole in the treatment for behavioral and psychiatric symptoms in elderly patients with dementia.Methods：Fifty-seven patients with senile dementia were randomly allocated to two groups and were treated with Risperidone or Aripiprazole for twelve weeks respectively.The behavioral pathology in Alzheimer＇s disease Scale（BEHAVE-AD） and treatment emergent symptoms scale（TESS） were used to evaluate efficacy and adverse effects respectively before and at the end of 4,8,12 weeks of treatment.Results： The BEHAVE-AD scores in both groups decreased significantly after treatment（P0.01）.There was no significantly difference in the decrease of BEHAVE-AD scores between two groups（P0.05）,and there was no significantly difference in the side effects between two groups（P0.05）.The efficacy rates of two groups were 82.76% and 78.57%,respectively.Conclusions： Risperidone is as effective as Aripiprazole for the treatment of senile dementia,with less side effects.
出处
《中国民康医学》
2011年第9期1072-1073,1144,共3页
Medical Journal of Chinese People’s Health
关键词
老年痴呆
精神行为症状
利培酮
阿立哌唑
Senile dementia
Behavioral and psychiatric symptoms
Risperidone
Aripiprazole
