摘要
目的应用超声斑点追踪成像技术观察慢性心力衰竭(CHF)患者左心室长轴各节段心肌及整体心肌二维应变的变化,评价其左室收缩的不同步情况及左室收缩功能。方法分别收集30例CHF患者与30例正常人的心尖左室长轴切面、心尖四腔切面及心尖二腔切面的连续3个心动周期图像。应用GE Echo PAC PC SW-Only软件分析图像,测量各节段心肌的峰值收缩应变值(S)及达峰时间、各切面峰值收缩总应变(GLS)及左室长轴平均总应变(GLS-Avg),得出各切面、各节段时间-应变曲线及18节段的应变牛眼图。同时用实时三平面左室容积法测得左室射血分数(LVEF)。结果 CHF组左室长轴各节段的S和各切面的GLS均较正常对照组明显降低(P<0.01);GLS-Avg与LVEF值具有正相关(r=0.89,P<0.05);多数节段(14/18)纵向应变达峰时间提前(P<0.05);CHF组左室18节段间最大达峰时间差增大(P<0.05),提示其左室收缩功能受损并出现左室收缩的不同步。结论超声斑点追踪成像技术可用于定量测量左室整体及局部心肌的应变,分析CHF患者左室收缩的不同步情况及GLS-Avg与LVEF的关系。
Objective To obverse two-dimensional strain changes of regional and global cardiac muscle in long axis of left ventricle（LV）in patients with chronic heart failure（CHF）using speckle tracking imaging（STI）,in order to asses the characteristics of LV systolic dyssynchrony and LV systolic function in patients with CHF.Methods The images of echocardiographic examinations were performed in 30 chronic heart failure patients verified by clinical diagnosis and 30 normal control subjects from apical long axis chamber,4 chamber and 2 chamber views of three consecutive cardiac cycles were acquired.Analyzed these images using a software of GE Echo PAC PC SW-Only,these parameters included peak systolic strain,its time to peak from each segment,global longitudinal peak systolic strain（GSL）and average global strain（GSL-Avg）from each view were measured in control and CHF group.As well as time-strain curves from each view and segment and 18 segments strain Bull-Eyes pie were obtained.Meanwhile,LV ejection fraction（EF）was calculated through real time tri-plane LV volume rule.Results The parameters S of each segment and GSL of each view in CHF patients were significantly lower than those of controls（P〈0.05）.There were a high correlation between EF and GSL-Avg（r=0.89）.Time to peak longitudinal strain in most LV segments（14/18）in CHF were significantly advanced than that of controls（P〈0.05）.The maximum difference of time to peak systolic longitudinal strain among 18 segments was enlarged in CHF group（P〈0.05）.Patients with CHF had impaired LV systolic function and resulted in LV dyssynchrony.Conclusion STI may measure quantitatively strain of regional and global cardiac muscle in long axis of LV.LV systolic dyssynchrony and correlation between EF and GSL-Avg in CHF were evaluated exactly using STI echocardiography.
出处
《安徽医科大学学报》
CAS
北大核心
2011年第4期369-373,共5页
Acta Universitatis Medicinalis Anhui
基金
安徽省高校自然科学基金重点项目(编号:KJ2010A175)
