摘要
目的:了解母亲分娩前乙型肝炎病毒核糖核酸(hepatitis B virus DNA,HBV DNA)载量对婴儿经过乙型肝炎疫苗联合乙型肝炎免疫球蛋白(hepatitis B immunoglobulin,HBIG)预防接种后免疫应答的影响。方法:选择2008年2月至2010年2月在东南大学附属第二医院住院分娩,母亲为乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性,婴儿出生时HBV DNA及HBsAg均为阴性者128例,按照母亲分娩时HBV DNA载量分A、B、C 3组,选择母亲为HBsAg阴性的婴儿21例为对照组即D组,各组婴儿行相同的预防接种,相同时段实验室检测乙型肝炎表面抗体(hepatitis B surface antibody,HBsAb)浓度。结果:A、B、C、D 4组婴儿在1个月时HBsAb平均浓度分别是(240.19±79.34)、(248.58±57.07)、(240.87±61.97)、(266.03±70.93)mU/ml,各组比较差异无统计学意义(F=0.666,P=0.574);2个月时各组HBsAb平均浓度分别是(155.87±97.78)、(155.72±141.11)、(196.90±141.51)、(175.26±105.34)mU/ml,各组比较差异无统计学意义(F=0.884,P=0.451);7个月时各组HBsAb平均浓度分别是(766.86±314.27)、(754.30±363.56)、(687.18±326.45)、(888.68±247.83)mU/ml,各组比较差异无统计学意义(F=0.857,P=0.466)。结论:母亲产前HBV DNA载量对婴儿1、2、7个月时HBsAb平均浓度无影响;各组婴儿经过联合预防接种后在1个月时都出现了具有保护性的HBsAb,2个月时HBsAb平均浓度均有下降,婴儿对乙型肝炎疫苗联合免疫的免疫应答不受母亲分娩前HBV DNA载量的影响。
Objective： To investgate the influence of mothers＇ hepatitisa B virus（HBV） DNA quantity on immunologic response of infants inoculated with hepatitis B vaccine combined with hepatitis B immunoglobulin（HBIG）.Methods：From Feb 2008 to Feb 2010,128 full-term infants born in Nanjing Second Hospital Affiliate to Southeast University with negative HBV DNA and hepatitis B surface antigen（HBsAg）,together with positive HBsAg of their mothers were selected and divided into three groups（A,B and C） according to their mothers＇ HBV DNA quantity,the control group（D） was composed of 21 infants with their mothers had negative HbsAg.All groups were given the same preventive inoculation,and the concentrations of hepatitis B surface antibody（HBsAb）were examined at the same time.Results：The average concentrations of HBsAb in groups A,B,C and D were（240.19±79.34）,（248.58±57.07）,（240.87±61.97） and（266.03±70.93）mU/ml in one-month infants,（155.87±97.78）,（155.72±141.11）,（196.90±141.51） and（175.26±105.34）mU/ml in two-month infants,and（766.86±314.27）,（754.30±363.56）,（687.18±326.45） and（888.68±247.83）mU/ml in seven-month infants,respectively.There was no significant difference among these 4 groups at the same timepoint（F=0.666,P=0.574;F=0.884,P=0.451;F=0.857,P=0.466,respectively）.Conclusion：The prenatal HBV DNA quantity had no effect on the levels of HBsAb in 1,2 and 7 months infants.The antibody produced in the first month after combined immunization and decreased in the second month.The immunologic response of infants was not affected by mothers＇ HBV DNA quantity.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2011年第4期561-564,共4页
Journal of Nanjing Medical University(Natural Sciences)
