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骨关节炎软骨细胞死亡机制研究 被引量：2

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摘要 骨关节炎（osteoarthritis，OA）是一种慢性退行性骨关节疾病，主要病理改变为关节软骨完整性的破坏，即软骨细胞的减少和细胞外基质的降解，还可累及软骨下骨，并伴有大量骨赘形成。软骨细胞参与细胞外基质的合成和修复，软骨细胞的减少必然导致细胞外基质的合成减少，而细胞外基质的缺损又会增加细胞对死亡信号的敏感性。
作者 许珂 许鹏
机构地区 西安交通大学医学院医疗系 西安市红十字会医院关节外科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第4期271-274,共4页 Chinese Journal of Rheumatology
关键词 软骨细胞 骨关节炎 死亡机制 细胞外基质 退行性骨关节疾病 关节软骨 病理改变 软骨下骨
分类号 R684.3 [医药卫生—骨科学]
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参考文献25

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二级参考文献9

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共引文献8

同被引文献19

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中华风湿病学杂志
2011年 第4期

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