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组织因子途径抑制物及其多态性与血栓性疾病 被引量：2

Tissue Factor Pathway Inhibitor and its Polymorphisms with Thrombosis
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摘要 炎症反应与血栓性疾病的发生、发展密切相关。现在认为,氧化应激可能是血管内皮功能失调和损伤的核心环节,许多炎性介质可促进氧化应激反应,诱导组织因子（tissue factor,TF）释放。TF一方面是炎性反应的后果;另一方面,TF本身可起到前炎性反应的作用,加重炎性反应进程。组织因子途径抑制物（tissue factor pathway inhibitor,TFPI）是TF的生理抑制剂,对冠心病等起保护作用。
作者 云雁 张冬霞 韩轩茂
机构地区 包头医学院第一附属医院血液科
出处 《血栓与止血学》 2011年第2期84-85,共2页 Chinese Journal of Thrombosis and Hemostasis
关键词 组织因子途径抑制物 血栓性疾病 多态性
分类号 Q75 [生物学—分子生物学]
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参考文献15

  • 1ENJYOJI K,EMIM,MUKAI T,et al.Human tissue factor pathway inhibitor(TFP I) gene:complete genomic structure and localization in the genetic map of chromosome 2q[J].Genomics,1993,17 (2):423-428.
  • 2SP RECHER CA,KISIELW,MATHEWES S,et al.Molecular cloning,expression,and partial characterization of a second human tissue factor pathway inhibitor[J].Proc Natl Acad Sci USA,1994,91(8):3353-3357.
  • 3DAHM A,VAN HYLCKAMA VLIEGA,BENDZB,et al.Low levels of tissue factor pathway inhibitor (TFPI) increase the risk of venous thrombosis[J].Blood,2003,101 (11):4387-4392.
  • 4WESTRICK RJ,BODARY PE,XU Z,et al.Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice[J].Circulation,2001,103 (25) 3044-3046.
  • 5HUANG J,FU G,YAO Q,CHENG G.Relation of thrombomodulin,TFPI and plasma antioxidants in healthy individuals and patients with coronary heart disease[J].Acta Cardiol,2008,63(3):341-346.
  • 6YAMAMOTO N,OGAWA H,OSHIMA S,et al.The effect of heparin on tissue factor and tissue factor pathway inhibitor in patients with acute myocardial infarction[J] Int J Cardiol,2000,75:267 -2741.
  • 7MITCHELL CT,KAMINENI A,PALMAS W,et al.Tissue factor pathway inhibitor,vascular risk factors and subclinicalatherosclerosis:the Multi-Ethnic Study of Atherosclerosis[J].Atherosclerosis,2009,207(1):277-283.
  • 8ALMASY L,SORIA JM,SOUTO JC,et al.A locus on chromosome 2 influences levels of tissue factor pathway inhibitor:results from the GAIT study[J].Arterioscler Thromb Vasc Biol,2005l,25(7):1489-1492.
  • 9DIDER M,BASSAM H,FREDERIC F,et al.A new T-287C polymorphism in the 5'regulatory region of the tissue factor pathway inhibitor gene:association study of the T2287C and C2399T polymorphism with coronary artery disease and plasma TFPI levels[J].Thromb Haemost,2000,84(2):244-249.
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血栓与止血学
2011年 第2期

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