摘要
以4-氯丁酰氯和氯苯为原料经酰化、合环得到环丙基-4-氯苯基酮,然后再以环丙基-4-氯苯基酮、盐酸羟氨和对硝基苄溴为原料,采用"一锅法"合成了杀虫剂氟螨脲的中间体1-硝基-4-(α-环丙基-4-氯苯甲亚胺氧基甲基)苯,收率70.6%。对产物及中间体的结构进行了1H NMR和IR表征。通过工艺条件优化,简化了反应步骤,提高了收率。
4-Chlorophenyl cyclopropyl ketone is synthesized by acylation and cyclization with 4-chlorobutyryl chloride and chlorobenzene as starting materials.Intermediate of flucycloxuron,an insecticide,（4-chlorophenyl）（cyclopropyl）methanone O-（4-nitrobenzyl）oxime is obtained in ＂one-pot＂ reaction with the 4-chlorophenyl cyclopropyl ketone,hydroxylamine hydrochloride and p-Nitrobenzyl bromide as starting materials,the yield was 70.6%.The structure of the product and intermediates is characterized by 1H NMR and IR.The process can be simplified and the yield of（4-chlorophenyl）（cyclopropyl）methanone O-（4-nitrobenzyl）oxime increased through optimization.
出处
《桂林理工大学学报》
CAS
北大核心
2011年第1期118-122,共5页
Journal of Guilin University of Technology
