摘要
目的 通过对Ⅱ型糖尿病家庭聚集性的分析，探讨遗传因素在糖尿病患者一级亲属成员发病中所起的作用及其相对危险度。方法 采用以人群为基础的遗传流行病学病例对照研究方法，对３６３ 例Ⅱ型糖尿病先证者家系及２９１ 例人群对照家系进行了调查。结果 先证者家系一级亲属糖尿病的患病率为３ ．９４ ％ ，对照组一级亲属为１ ．０９ ％ ，相对危险度为３ ．６２ ，各组血缘亲属的相对危险度均在３ ．０ 以上；糖尿病先证者诊断时年龄越轻，其一级亲属的糖尿病患病率和相对危险度越高，其家系内发生多例糖尿病病例的可能性越大。结论 Ⅱ型糖尿病具有明显的家庭聚集倾向，其一级亲属对糖尿病的遗传易感性较高，是糖尿病预防和控制的重点人群。
Objective To estimate the genetic susceptibility and its relative risk ( RR ) in the first degree relatives of type 2 diabetes mellitus (DM) through family aggregation analysis. Methods A population based case control study including 654 pedigrees (363 index cases and 291 controls) was carried out. Results The prevalence rate in the first degree relatives of DM probands was 3.94%, significantly higher than that in the controls (1.09%), with a relative risk of 3.62 (χ 2=36.5, P <0.001). The RRs in different consanguineal relatives were all higher than 3.0. The younger was the probands at diagnosis for DM, the higher its prevalence rates and RRs among their relatives was and the more likelihood that more than one case of DM occurred in them. Conclusion Significant family aggregation and higher genetic susceptibility were found in the first degree relatives of DM, on whom prevention and treatment for DM should be focused.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1999年第4期206-208,共3页
Chinese Journal of Preventive Medicine
