摘要
疫苗免疫是目前防控流感病毒感染最有效的策略。现有流感疫苗在不同亚型间的交叉保护力较差,并且由于HA和NA蛋白存在抗原漂移和转换现象,极大地影响了现有疫苗的免疫保护效果,甚至导致疫苗免疫失败。而动物模型研究结果显示,基于流感病毒基因组保守区域的疫苗能够对不同型或亚型的流感病毒产生广谱的交叉保护,本文主要介绍基于M2e、HA和NP的通用型流感型疫苗研究进展。
Vaccination is the primary strategy for prevention and control of influenza.Current influenza vaccines have poor cross-clade protective immunity.In addition,frequent mutation of the viral surface proteins HA and NA,which results from antigenic drift or shift,largely restricts the use of these vaccines against divergent influenza A viruses.Universal influenza vaccines based on the conserved sequences of M2e,HA and NP protein presented broad cross-protective immunity in animal studies,which suggested a promising future for influenza vaccine research.This review describes the advancements in the research and development of universal influenza vaccines.
出处
《中国动物传染病学报》
CAS
2011年第1期76-82,共7页
Chinese Journal of Animal Infectious Diseases
基金
中国农业科学院上海兽医研究所院所长基金项目(2010JB01)
上海市科技兴农重点攻关项目(沪农科攻(2009)第5-2号)
