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A型流感病毒M2蛋白疫苗的研究进展

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摘要 流感是由流感病毒引起的一种呼吸道传染病。目前应用的流感疫苗主要是针对流感病毒的膜蛋白HA和NA，但HA和NA存在抗原漂移和抗原转变问题，需要不断改换制备疫苗用的毒株。解决办法之一是研制一种“通用型”流感疫苗。M2蛋白是流感病毒第三种跨膜蛋白，具有离子通道作用，而且其基因序列高度保守。
作者 徐一 张智清
机构地区 中国疾病预防控制中心病毒病预防控制所
出处 《中华实验和临床病毒学杂志》 CAS CSCD 北大核心 2009年第6期493-495,共3页 Chinese Journal of Experimental and Clinical Virology
关键词 A型流感病毒 蛋白疫苗 呼吸道传染病 流感疫苗 跨膜蛋白 抗原转变 抗原漂移 M2蛋白
分类号 R3 [医药卫生—基础医学]
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参考文献29

  • 1Zebedee SL, Lamb RA. Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J Virol, 1988,62 : 2762-2772.
  • 2Neirynck S, Deroo T, Saelens X, et al. A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat Med, 1999,5 : 1157-1163.
  • 3Treanor JJ, Tieruey EL, Zebedee SL, et al. Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice. J Virol, 1990,64: 1375-1377.
  • 4Ito T, Gorman OT, Kawaoka Y, et al. Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins. J Virol. 1991,65:5491-5495.
  • 5Takeuehi K, Lamb RA. Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport. J Virol, 1994,68 : 911-919.
  • 6Fiers W, De Filette M, Birkett A, et al. A " universal" human influenza A vaccine. Virus research , 2004 ,103 : 173-176.
  • 7Lamb RA, Lai C J, Choppin PW. Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc Natl Acad Sci U S A, 1981,78 : 4170-4174.
  • 8Lamb RA, Zebedee SL, Richardson CD. Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell, 1985,40 : 627-633.
  • 9Hughey PG, Roberts PC, Holsinger LJ, et al. Compans RW. Effects of antibody to the influenza A vires M2 protein on M2 surface expression and virus assembly. Virol, 1995,212 : 411-421.
  • 10Watanabe T, Watanabe S, Kida H, et al. Influenza A virus with defective M2 ion channel activity as a live vaccine. Virol, 2002, 299 : 266-270.

二级参考文献9

  • 1[1]Black R A,Rota P A,Gorodkova N,et al.Production of the M2 protein of influenza A virus in insect cells is enhanced in the presence of amantadine[J].J Gen Virol,1993,74(Pt8):1673-1677.
  • 2[2]Zebedee S L,Lamb R A.Influenza A virus M2 protein;monoclonal antibody restriction of virus growth and detection of M2 in virions[J].J Virol,1988,62(8):2762-2772.
  • 3[3]Treanor J J,Tierney E L,Zebedee S L,et al.Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice[J]. J Virol,1990,64(3):1399-1402.
  • 4[4]Ito T,Gorman OT,Kawaoka Y.Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins[J].J Virol,1991,65(10):5491-5498.
  • 5[5]Slepushkin V A,Katz J M,Black R A,et al.Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein[J].Vaccine,1995;13(15):1399-1402.
  • 6[6]Neirynck S,Deroo T,Saelens X,et al.An universal influenza A vaccine based on the extracellular domain of the M2 protein[J].Nat Med,1999,5(10):1157-1163.
  • 7[7]Hahnenberger K M,Krystal M,Esposito K,et al.Use of microphysiometry for analysis of heterologous ion channels expressed in yeast[J].Nat Biotechnol,1996,14(7):880-883.
  • 8[8]Hennessey E S,Hashemzadeh-Bonehi L,Hunt L A,et al.Assembly of eukaryotic class Ⅲ (N-out,C-in) membrane proteins into the Escherichia coli cytoplasmic membrane[J].FEBS Lett,1993,331(1-2):159-161.
  • 9[9]Frace AM,Klimov A I,Rowe T,et al.Modified M2 proteins produce heterotypic immunity against influenza A virus[J].Vaccine,1999,17(18):2237-2244.

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中华实验和临床病毒学杂志
2009年 第6期

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