摘要
目的研究口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）中MMP-2和CyclinD1的表达水平,阐明其在口腔鳞癌发病中的临床意义。方法采用免疫组化法对40例口腔鳞癌标本和10例正常对照组标本中MMP-2、CyclinD1的表达量进行检测并比较分析。结果口腔鳞癌组的MMP-2和CyclinD1阳性表达率均高于对照组（P〈0.05）。MMP-2与CyclinD1在口腔鳞癌中的表达与患者的年龄无关（P〉0.05）;高~中分化患者的MMP-2阳性表达率较高（P〈0.01）,而低分化患者CyclinD1蛋白阳性表达率较高（P〈0.01）;临床分期为Ⅲ~Ⅳ期的患者MMP-2与CyclinD1阳性表达率高于Ⅰ-Ⅱ期的患者（P〈0.05或0.01）;有淋巴结转移的患者的MMP-2和CyclinD1蛋白阳性表达率均高于无淋巴结转移的患者（P〈0.05）。MMP-2和CyclinD1的表达呈负相关（rs=-0.56,P〈0.05）。结论 MMP-2和CyclinD1联合检测可作为OSCC早期诊断的指标,为尽早抑制口腔鳞癌侵袭、转移提供帮助。
Objective To investigate the expressions of MMP-2 and CyclinD1 in OSCC and the clinical significance.Methods The content of expressions of MMP-2 and CyclinD1 was detected and analyzed by immune histochemistry method in 40 cases with OSCC and 10 cases with normal oral tissues in control group.Results The rate of positive expressions of MMP-2 and CyclinD1 in the group of OSCC was averagely higher than that in the control group（P〉0.05）.The expressions of MMP-2 and CyclinD1 in OSCC had no correlation with the age of the patients（P〈0.05）.The rate of positive expression of MMP-2 in the patients of high and moderate differentiation was higher（P〈0.01）,while that of CyclinD1 in the patients of low differentiation higher（P〈0.01）,who were classified as patients of MMP-2 at the 3rd and 4th clinical stage and patients with CyclinD1 expression rate higher than those at the 1st and 2nd stage（P〈0.05 or 0.01）.The expression rate of MMP-2 and CyclinD1 in patients with lymph node metastases was averagely higher than those without（P〈0.05）.The expression of MMP-2 and CyclinD1 showed negative correlation（rs=-0.56,P〈0.05）.Conclusion Combined detection of MMP-2 and CyclinD1 can be applied as the early diagnostic index to inhibit infiltration and metastasis of OSCC.
出处
《右江医学》
2011年第2期137-139,共3页
Chinese Youjiang Medical Journal
