摘要
高效抗逆转录病毒治疗(HAART)的广泛使用很大程度上控制HIV/AIDS患者的HIV,使血浆HIV-RNA下降到检出限之下,显著降低了AIDS及其相关病症的发生,但实践证明感染者体内仍有病毒潜伏存储库。静息型CD4+T细胞HIV潜伏存储库是主要的存储库,同时也是根除HIV的主要障碍,具有半衰期长、持续时间长、容易反弹等特点,现有的治疗策略无法对其清除,寻找有效的抑制HIV存储库的治疗策略已成为治疗HIV/AIDS的重要目标。
With the advent of highly active antiretroviral therapy（HAART）,which could lead a substantial decline in the incidence of acquired immunodeficiency syndrome（AIDS）and AIDS-related mortality,control of viral replication is now possible.However,the persistence of various viral reservoirs in infected individuals exists.A pool of latently infected cells in the resting CD4＋T cell compartment has been one of the most extensively studied to date and is considered to be a major impediment to HIV eradication.It has been proved that long intrinsic half-life of such a latent HIV reservoir lead to bounce of disease easily.It has been proved the current strategies for the elimination of latent infection and resting CD4^＋ T cells can not be effective.To find effective strategies for suppression of latent HIV reservoir has become an important treatment for HIV/AIDS.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2011年第4期312-314,共3页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金面上项目"中西药合用对HIV存储库干预作用的探索研究"(30960492)
云南省科技厅社会发展科技计划专项"中西医药结合治疗艾滋病关键技术"(2009CA002)
