摘要
目的:探讨18F-FDG PET/CT对显像阳性的原发性肝癌行125I粒子植入治疗疗效价值的评价.方法:原发性肝癌患者39例,共55个肿瘤病灶,均于放射性125I粒子植入治疗前确定病灶为18F-FDG PET/CT显像阳性;放射性125I粒子植入治疗后2mo行PET/CT检查评价疗效,之后进行常规影像学(CT或MR)随访6mo,随访结果作为肿瘤病灶是否有治疗后残留的标准.结果:55个肿瘤病灶中常规影像学(CT或MR)随访6mo证实有肿瘤残留的病灶为21个,其中19个放射性125I粒子植入治疗后2mo行PET/CT评价为有残留,另外2个PET/CT评价为无残留;随访6mo证实无肿瘤残留的病灶34个,其中31个放射性125I粒子植入治疗后2mo行PET/CT评价为无残留,另外3个PET/CT评价为有残留.18F-FDG PET/CT在判断肿瘤残留方面的灵敏度和特异度分别为90.4%,91.2%.结论:18F-FDG PET/CT对显像阳性的原发性肝癌125I粒子植入后坏死灶与残留灶的区分有较高的灵敏度和特异度,能够较好地评价疗效,并能为进一步治疗提供指导作用.
AIM：To determine the role of 18F fluorodeoxy-glucose-positron emission tomography/computed tomography（18F-FDG PET/CT） in the surveillance of primary liver cancer treated by 125I seed implantation.METHODS：A total of 39 patients with primary liver cancer（55 lesions） whose 18F-FDG PET/CT scan was positive underwent PET/CT 2 months after 125I seed implantation.Imaging findings were compared with the results of radiological follow-up.RESULTS：There were 21 lesions with and 34 without residual viable tumor tissue which were confirmed by conventional radiological examinations at the implantation sites.In contrast,19 lesions with and 31 without residual viable tumor tissue were identified on 18F-FDG PET/CT.The diagnostic sensitivity and specificity of 18FFDG PET/CT were 90.4% and 91.2%,respectively.CONCLUSION：In patients with primary liver cancer whose 18F-FDG PET/CT scan is positive,PET/CT is a valuable method to assess the viability of tumor after 125I seed implantation.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第5期524-528,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金面上项目
No.30600156
30870692~~
关键词
原发性肝癌
125I粒子
18F-FDG
PET/CT
Primary liver cancer
125I seed
18F fluorodeoxyglucose positron emission tomography/computed tomography
