摘要
IEX-1基因于1993年被克隆。IEX-1在多种组织器官中表达,是一种凋亡相关调节蛋白。已有研究表明,IEX-1具有正性或负性调节细胞生长和凋亡作用,可抑制细胞生长,促进细胞凋亡;也可抑制细胞凋亡。且与病毒感染、心血管疾病有关,特别是在多种肿瘤中高表达。其调控机制种类繁多,过程复杂,至今尚未完全明确。深入研究其功能对理解疾病的发生机制有很重要的意义。
Immediate early response gene X-1（IEX-1） gene was discovered by Charles in 1993,which plays an important role in regulating apoptosis.Previous studies demonstrated that IEX-1 gene was expressed in a variety of human tissues and played an important role in regulating apoptosis and cell growth through a positive or negative way.It can inhibit cell growth and apoptosis.However,it can also promote cell apoptosis.There is evidence that IEX-1 is involved in viral infections and cardiovascular diseases and it is highly expressed in many tumor tissues.The regulatory mechanisms for IEX-1 under normal and pathophysiological conditions are complicated and remain largely unknown.In this paper,we reviewed the recent progress of IEX-1 in different disease models.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2011年第3期274-276,F0003,共4页
Journal of Central South University ：Medical Science
基金
国家自然科学基金(30571883)
湖南省自然科学基金(09JJ3081)~~
