摘要
目的建立注射用帕尼培南倍他米隆含量的测定方法,并研究与4种常用输液的配伍稳定性。方法用RP-HPLC法测定配伍后不同时间点的帕尼培南和倍他米隆的含量,同时考察其外观、颜色、pH值变化。结果室温下放置6h,其含量、pH值、外观均无明显变化,但与10%葡萄糖注射剂和葡萄糖氯化钠溶液配伍12h后,溶液颜色明显变黄。结论注射用帕尼培南倍他米隆与4种输液配伍在6h内稳定,但与10%葡萄糖注射剂和葡萄糖氯化钠溶液配伍长时间放置需谨慎。
AIM To establish a method for the determination of panipenem and betamipron for injection,research the stability of panipenem and betamipron for injection with the four common clinical infusion fluids.METHODS The contents of panipenem and betamipron in the fluids were determined at different time points by RP-HPLC,the outward appearance,color variety and pH value were investigated in the same time.RESULTS Within 6 h,the contents,the outward appearance and the pH value of panipenem and betamipron had no apparent changes at room temperature;but after 12 h,the color variety could be observed clearly in 10%glucose,the same color variety could be observed in glucose and sodium chloride injection.CONCLUSION Panipenem and betamipron for injection are stable in the four fluids within 6 h,but it must be used carefully with the 10%glucose and glucose and sodium chloride injection after a long time delay.
出处
《中国临床药学杂志》
CAS
2011年第2期102-105,共4页
Chinese Journal of Clinical Pharmacy
