摘要
目的检测扁平苔藓皮损中肝细胞生长因子(HGF)和基质金属蛋白酶-9(MMP-9)的表达情况,探讨其在扁平苔藓发病中的意义。方法应用免疫组化法和RT-PCR法测定30例扁平苔藓及30例正常皮肤组织中HGF和MMP-9的表达水平。结果扁平苔藓组中HGF和MMP-9的表达率均高于正常对照组(P<0.01),且二者在扁平苔藓皮损中的表达呈正相关(r1=0.391,P1=0.032;r2=0.375,P2=0.041)。结论 HGF和MMP-9的高表达可能参与了扁平苔藓的发病。
Objective To explore the expression of hepatocyte growth factor（HGF） and metalloproteinase- 9（ MMP- 9） in lichen planus,and investigate the function in pathogenesis of lichen planus. Methods The expression of HGF and MMP - 9 was assayed by RT - PCR and immunohistoehemistry in 30 LP lesions and 30 normal skins. Results The expression of HGF and MMP - 9 in LP lesions was stronger than that in normal skins（ P 〈 0.01 ） , and HGF was positively related to the expression of MMP- 9 in LP lesions （r1 = 0. 391 ,P1 = 0. 032; r2 =0. 375, P2 = 0. 041 ）. Conclusion The increased expression of HGF and MMP- 9 may contribute to the formation and progression of lichen planus.
出处
《医学研究杂志》
2011年第3期123-124,共2页
Journal of Medical Research
