摘要
该文以卡拉胶为原料,采用双氧水降解,制备出一种低密度脂蛋白净化剂.考察了净化剂浓度、净化体系pH值对血浆低密度脂蛋白胆固醇（LDL-C）净化效果的影响,得到较优化的诱导沉淀条件.体外间歇诱导沉淀实验表明,该净化剂对血浆总胆固醇（TC）的平均净化率为66.1%,对LDL-C平均净化率为83.7%,对高密度脂蛋白胆固醇（HDL-C）平均净化率为24.3%,对总蛋白质（TP）的平均清除率为13.5%,对LDL-C的清除有较好的选择性.
An agent for Low-density Lipoprotein-apheresis was prepared by degradation of carrageenan with hydrogen peroxide.The effects of the purifying agent concentration and pH value on the selective precipitation of low density lipoprotein cholesterol（LDL-C） was investigated,the optimal conditions for LDL-precipitation were obtained.The results of precipitation in vitro showed that the average purifying percentage for LDL-C,total cholesterol（TC）,high-density lipoprotein cholesterol（HDL-C） and total protein（TP） was 83.7%,66.1%,24.3% and 13.5% respectively.The purifying agent possesses good selectivity in removal of LDL-C.
出处
《中国血液流变学杂志》
CAS
2011年第1期17-20,共4页
Chinese Journal of Hemorheology
关键词
卡拉胶
降解
低密度脂蛋白净化
Carrageenan
degradation
Low-density lipoprotein-apheresis
