摘要
目的探讨腺瘤型原发性醛固酮增多症的临床特点。方法回顾性分析46例经手术病理证实的腺瘤型原发性醛固酮增多症患者的临床资料。结果所有患者均伴有高血压,以高血压为首发症状者43例(93.48%),其中1、2、3级高血压分别为2.17%、17.39%、80.44%;伴肌无力、乏力或肢端麻木者23.52%。平均血钾浓度为(3.37±0.38)mmol/L,其中低钾血症者26例(56.52%);低血浆肾素活性者37例(80.43%),血浆醛固酮水平增高者38例(82.62%);肾上腺CT扫描对腺瘤型原发性醛固酮增多症的诊断阳性率为93.48%。结论腺瘤型原发性醛固酮增多症主要表现为重度高血压伴低肾素活性及高醛固酮血症,低钾血症的发生率少于60%;肾上腺CT扫描对腺瘤型原发性醛固酮增多症的诊断有重要价值。
Objective To investigate the clinical characteristics of patients with aldosterone - producing adenoma （APA）. Methods The clinical data of 46 cases with APA who were confirmed by postoperative pathological diagnose were analyzed retrospectively. Results All cases had hypertension and hypertension suffered as the primary symptom in 93.48% patients. The prevalence of 1,2 and 3 stage hypertension in these subjects were 2.17%, 17.39% and80.44%, respectively. 23.52% of patients had weakness or periodic paralysis. The average serum potassium level was （3.37 ± 0.38 ） mmol/L. The incidence of hypokalemia was 56.52%. The plas- ma renin activity was 〈 1 ng · ml^-1 · h^-1 in 80.43% of the patients. The plasma aldosterone level was 〉 12 ng/dl in 82.62% of the patients. The diagnostic sensitivity of adrenal CT scaning was 93.48% in APA patients. Conclusions The majority present severe hypertension with low rennin activity and high aldosterone level in APA patients. The incidence of hypokalemia was less than 60%. Adrenal CT scaning play an important role in diagnose of APA.
出处
《新疆医学》
2011年第3期8-10,共3页
Xinjiang Medical Journal
