摘要
目的探讨乳腺癌患者ER、PR、c-erbB-2的表达,及3者与临床病理因素的相关性。方法采用回顾性分析,通过免疫组织化学方法检测乳腺癌患者ER、PR、c-erbB-2的表达,探讨其与临床的关系(包括患者年龄、肿瘤部位、肿瘤直径、肿瘤所在象限、有无淋巴结转移、临床分期和病理分型),并做统计学处理。结果乳腺癌患者ER阳性率为57.60%(800/1 389),PR阳性率为54.93%(763/1 389),c-erbB-2的阳性率为59.03%(820/1 389)。ER,PR表达与c-erbB-2表达呈负相关,ER与PR表达呈正相关。ER、PR阳性表达与患者肿瘤部位、肿瘤所在象限和病理分型差异无显著性(P>0.05),两者与临床分期和肿瘤直径的差异有显著性(P<0.05),PR阳性表达与患者年龄和有无淋巴结转移差异有显著性(P<0.05)。c-erbB-2阳性表达与患者年龄、肿瘤部位、肿瘤所在象限和临床分期的差异均显著性(P>0.05),但与淋巴结转移、病理分型、肿瘤直径大小的差异有显著性(P<0.05)。结论乳腺癌患者ER、PR、c-erbB-2的检测已广泛应用于临床,3者联合检测有助于乳腺癌患者临床疗效和预后的判断。
【Objective】 To investigate the expression of ER,PR,c-erbB-2 in breast cancer tissue and the relationship between them and clinical pathology.【Methods】 The expression of ER,PR,c-erbB-2 in 1 389 cases of breast cancer tissue were assessed by immunohistochemistry,and the correlation between that and its clinical significance was statistically analyzed.【Results】 Positive expression rate of ER,PR,c-erbB-2 in 1 389 cases of breast cancer tissue was 57.60%（800/1 389）,54.93（763/1 389）,59.03%（820/1 389）.The expression of ER,PR and c-erbB-2 is negative correlation.The expression of ER,PR is positive correlation.They had no relationship with tumor＇s location,tumor＇s qudrant,pathological classification（P 0.05）,but they had positive correlation with TNM staging and tumor＇s size（P 0.05）.The expression of PR had positive correlation with patient＇s age and lymphstic metastasis（P 0.05）.The expression of c-erbB-2 had no relationship with patient＇s age,tumor＇s location,tumor＇s quadrant and TNM staging（P 0.05）,but had close relationships with lymphatic metastasis,pathological classification and tumor size（P 0.05）.【Conclusion】 The test of breast cancer patients with ER,PR,c-erbB-2 has been widely used in clinical.Combined detection of them may be helpful to clinical treatment and prognostic judgment on breast cancer patients.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第8期998-1001,共4页
China Journal of Modern Medicine
