摘要
目的探讨ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白表达在新疆维、汉民族乳腺癌患者间的异同。方法维吾尔族和汉族乳腺癌患者按发病时的年龄及肿瘤分期进行1∶1配对,共收集83对病例,采用免疫组化二步法分别检测ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白在两民族乳腺癌患者的表达情况并进行对比分析。结果维吾尔族乳腺癌患者ER、PR、Her-2、nm23、MDR、LRP及ki-67阳性表达率分别为63.9%、55.4%、28.9%、93.3%、3.6%、44.4%、65.1%,汉族乳腺癌患者阳性表达率分别为61.4%、62.7%、39.8%、97.6%、7.5%、46.5%、76.7%,两组阳性表达率差异均无统计学意义(P=0.724、0.330、0.139、0.277、0.496、0.438、0.061)。维吾尔族和汉族三阴性乳腺癌[ER(-),PR(-),Her-2(-)]的分布差异无统计学意义(χ2=0.182,P=0.669)。结论新疆维、汉民族乳腺癌患者ER、PR、Her-2、nm23、MDR、LRP及ki-67蛋白表达不存在民族差异。
Objective To study the difference of immunohistochemisty characteristics including ER,PR,Her-2,nm23,MDR,LRP and ki-67in female breast cancer patients between Uygur and Han patients. Methods83 pairs of patients with breast cancer by matched-pairs design including ages and clinical TNM stage between Uygur patients and Han patients were analysed by using chi square test. Results The immunohistochemisty characteristics including ER,PR,Her-2,nm23,MDR,LRP and ki-67 between two nationals had no signifantly statistical difference（P =0.724,P =0.330,P =0.139,P =0.277,P =0.496,P =0.438,P =0.061）There also had no statistical difference in triple-negtive breast cancer between two nationals（x2=0.182,P =0.669）.. Conclusion There were no statistical difference between Uygur and Han nationals in immunohistochemisty characteristics including ER、PR、Her-2、nm23、MDR、LRP and ki-67.
出处
《新疆医科大学学报》
CAS
2011年第12期1347-1349,1354,共4页
Journal of Xinjiang Medical University
基金
国家自然科学基金资助项目(编号:30960435)
新疆维吾尔自治区青年科学基金项目(编号:2011211B53)
