摘要
目的探讨2型糖尿病(T2DM)患者血清内脂素与尿清蛋白排泄率(UAER)的关系。方法采用免疫透射比浊法和ELISA法检测300例T2DM患者的尿微量清蛋白和血清内脂素水平,同时测定血清胰岛素水平和糖化血红蛋白A1c(HbA1c),计算胰岛素抵抗指数。按UAER水平将其分为正常蛋白尿组(n=170)、微量清蛋白尿组(n=70)和临床清蛋白尿组(n=60)。结果从微量清蛋白尿组到临床清蛋白尿组,血清内脂素水平依次增高,差异均有统计学意义(P<0.01)。T2DM患者血清内脂素水平与UAER呈显著正相关(γ=0.652,P<0.01),调整年龄、性别、血压及血脂等的影响后,血清内脂素水平仍与UAER呈显著正相关(γ=0.378,P<0.05)。多元逐步回归分析结果显示,内脂素和HbA1c是UAER独立影响因素(P<0.01,r2=0.674)。结论 T2DM体内内脂素水平与UAER密切相关,一定程度上可反映糖尿病肾脏病变程度。
Objective To investigate the association between serum visfatin and urinary albumin excretion rate（UAER）in patients with type 2 diabetes mellitus（T2DM）.Methods The immunoturbidimetry and ELISA methods were used to measure urinary micro-albumin and serum visfatin levels in 300 cases of type 2 diabetic patients.The serum insulin and HbA1c levels were tested,and then the HOMA-IR was calculated.All 300 cases were divided into the normoalbuminuric group（n=170）,the microalbuminuric group（n=70）and the macroalbuminuric group（n=60）,based on UAER levels.Results The serum visfatin levels were considerably increased in all groups in ascending order from normoalbuminuric group to macroalbuminuric group,with significant differences among the 3 groups（P0.01）.The serum visfatin levels of T2DM patients had positive correlation with the level of UAER（γ=0.652,P0.01）,even after eliminating the influence of age,gender,blood pressure and blood lipid profiles（γ=0.378,P0.05）.The result of multiple stepwise regression analysis showed that visfatin and HbA1c were the independent influencing factors for UAER,（P0.01,r2=0.674）.Conclusion Serum visfatin level is closely related to UAER,to some extent,reflecting the severity of the renal lesions in T2DM.
出处
《检验医学与临床》
CAS
2011年第8期909-910,913,共3页
Laboratory Medicine and Clinic
