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PAK5在凋亡级联反应中的调节作用 被引量：3

Role of PAK5 in Regulating Apoptotic Cascade
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摘要 PAK5为PAKs家族中新近发现的成员.PAKs是一类通过与Rac和Cdc42结合而激活的高度保守的蛋白酶.PAKs在细胞骨架、神经生长、激素信号传导、基因转录等生理活动中起着重要的调控作用.PAK5在大脑组织中高度表达,在细胞中定位于线粒体.PAK5与神经生长、增强微管的稳定性以及阻止细胞凋亡等活动密切相关.本文就PAK5的结构、表达部位和功能以及其在调控凋亡级联反应中的作用等方面做了简要综述. p21-activated kinase 5 （ PAK5） is a recently identified member of p21-activated kinases （PAKs）.They are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. PAKs are important regulators of actin cytoskeletal dynamics,neurite outgrowth,cell survival,hormone signalling and gene transcription. PAK5 is highly expressed in the brain and constitutively localized to mitochondria. PAK5 plays an important role in neurite outgrowth,microtubule stabilization and apoptosis through BAD phosphorylation. This review will focus on the structure,expression,function of PAK5 and its role in regulating apoptotic cascade.
作者 谢宇 孙新 关新刚 陈建光
机构地区 北华大学生命科学中心 北华大学药学院
出处 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2011年第3期224-227,共4页 Chinese Journal of Biochemistry and Molecular Biology
基金 吉林省科技厅项目(No.20080440-1 No.20080906) 吉林省教育厅项目(No.2009-404)资助~~
关键词 P21活化的激酶(PAK5) 细胞凋亡 线粒体 p21-activated kinase 5 （PAK5） apoptosis mitochondria
分类号 Q78 [生物学—分子生物学]
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参考文献25

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同被引文献87

  • 1Field J, Manser E. The PAKs come of age : celebrating 18 years of discovery[ J]. Cell Logist,2012,2(2) :54-58.
  • 2Dan C, Nath N, Liberto M, et al. PAKS, a new brain- specific kinase, promotes neurite outgrowth in N1E-115 cells [ J ]. Mol Cell Biol, 2002,22 ( 2 ) :567-577.
  • 3Wu X, Frost J A. Multiple Rho proteins regulate the subcellular targeting of PAK5 [ J ]. Biochem Biophys Res Commun, 2006,351 (2) : 328-335.
  • 4Ching Y P,Leong V Y,Wong C M,et al. Identification of an autoinhibitory domain of P21-activated protein kinase 5 [ J ]. J Biol Chem,2003,278(36) :33621-33624.
  • 5Minden A. PAK4-6 in cancer and neuronal development[J]. Cell Logist,2012,2(2) :95-104.
  • 6Luo T,Xu Y,Hoffman T L,et al. Inca:a ovel P21-activated kinase-associated protein required for cranial neural crest development [ J ]. Development, 2007,134 (7) : 1279 - 1289.
  • 7Wells C M ,Jones G E. The emerging importance of group II PAKs [ J ]. Biochem J, 2010,425 ( 3 ) : 465-473.
  • 8Ye D Z, Field J. PAK signaling in cancer [ J ]. Cell Logist,2012,2 (2) :105-116.
  • 9Wen Yiyang, Zheng Junnian, Pei Dongsheng. An oncog- enic kinase : putting PAK5 forward [ J ]. Expert Opin Ther Targets ,2014,18 (7) :807-815.
  • 10Wang X X, Cheng Q, Zhang S N, et al. PAKS-Egrl-MMP2 signaling controls the migration and invasion in breast cancer cell [ J ]. Turnout Biol, 2013, 34 ( 5 ) : 2721-2729.

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中国生物化学与分子生物学报
2011年 第3期

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