摘要
在体外循环过程中,血小板可经各种途径被激活,导致α-颗粒释放,发生粘附、聚集、收缩、释放等反应,导致术后血小板数量和质量的下降。通过在围体外循环期使用某些药物可对血小板进行功能性保护,而血小板分离技术可使血小板避免体外循环的打击,得到数量和功能的双重保护。本文将就体外循环期间血小板保护的研究进展作一综述。
Platelets can release α-granules when activated by various kinds of factors and then proceed to adhension,aggrega-tion,contraction and releasing.Therefore,the quantities and qualities of platelets are decreased after cardiac operation.The function of platelets can be protected by some drugs used during cardiopulmonary bypass.Plateletphoresis can preserve the quantities and function of platelets by making some platelets avoid cardiopulmonary bypass.This review addresses the advance of platelet preservation during cardiopulmonary bypass.
出处
《现代生物医学进展》
CAS
2011年第7期1391-1393,共3页
Progress in Modern Biomedicine
基金
南京市卫生局科技发展项目(YKK06066)
关键词
体外循环
血小板保护
血小板分离技术
cardiopulmonary bypass
platelet preservation
plateletphoresis
