摘要
目的：检测心力衰竭（ Ｈ Ｆ）大鼠循环肾素血管紧张素系统（ Ｒ Ａ Ｓ）、血浆纤溶酶原激活物抑制物（ Ｐ Ａ Ｉ）活性变化以及依那普利干预的影响，以证明 Ｈ Ｆ 时 Ｒ Ａ Ｓ对内源性纤溶系统的作用并讨论其意义。方法：建立大鼠动静脉瘘 Ｈ Ｆ模型，将其分成单纯 Ｈ Ｆ组及依那普利治疗组，另将大鼠作假手术作为对照组（每组各１０只）。分别于手术前３ ｄ、术后９ ｄ 及３０ ｄ 检测血浆肾素活性（ Ｐ Ｒ Ａ）、血管紧张素Ⅱ（ ＡｎｇⅡ）及血浆纤溶酶原激活物抑制物活性（ Ｐ Ａ ＩⅠ）。结果：① Ｐ Ｒ Ａ 及 ＡｎｇⅡ浓度：各组间于手术前及假手术组手术前后均无显著差异（均 Ｐ ＞ ０．０５）。手术后９ ｄ 时 Ｈ Ｆ组及依那普利组均较对照组明显升高，也较手术前明显升高（均 Ｐ ＜ ０．０５），尤以 Ｈ Ｆ 组更明显，手术后３０ ｄ 时均下降， Ｈ Ｆ组仍明显高于对照组（ Ｐ ＜ ０．０５），而依那普利组已回到手术前水平。② Ｐ Ａ ＩⅠ活性：手术前各组间及对照组手术前后均无明显差异（均 Ｐ ＞ ０．０５）。术后依那普利略高于对照组，但差别不显著（ Ｐ ＞ ０．０５），手术后 Ｈ Ｆ组较另两组明显升高（ Ｐ ＜ ０．０５），但亦呈下降趋势。结论： Ｈ Ｆ时 Ｒ Ａ Ｓ激活与?
Objective:The effect of renin angiotensin system (RAS) and intervention with Enalapril on endogenous fibrinolytic system were evaluated.Methods:The heart failure model rats were established by arterio venous shunt operation.Then they were divided into heart failure (HF) group and enalapril treated group.Sham operated rats were used as control group.Each group contained 10 rats.Plasma renin aetivity (PRA),angiotensin Ⅱ (AngⅡ) and plasminogen activetor inhibitor activity (PAI Ⅰ) were determined 3 days before and 9、30 days after operation.The levels were compared.Result:①PRA、AngⅡ:There were no significant differences between 3 groups before operation and after sharn operation of the control group (P> 0.05 ).9 days after operation,the levels of HF group and enalapril group increased significantly than control group and before?$$$LU Yi sheng,HUANG Hong qian,YANG Yong hong,et al (Department of Orthopedics,The 117th Hospital of PLA, Zhejiang Hongzhou,310013,China) Abstract:\ Aim:To evaluate the results of 17 cases treated with transpedicle cuneiform osteotomy for correction of kyphosis due to ankylosing spondylitis.Methods:The process osteotomy were:removed one or two bone masses high about 3 cm from posterior column of thoracolumbar vertebrae,removed bilateral pedicles,removed posterior 2/3 cancellous bone of vertebral body,closed osteotomy space,performed apparatus internal fixation.Postoperative follow up averaged 2.5 years.Results:The results of 17 cases were improved outward appearance,correction of malformation was satisfactory.Conclusions:Transpedicle cuneiform osteotomy for correction of kyphosis due to ankylosing spondylitis is a satisfactory and reliable technique.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1999年第8期372-375,共4页
Journal of Clinical Cardiology
