摘要
实验采用同龄自发性高血压大鼠(SHR)和Wistar-Kyoto大鼠(WKY),各随机分为对照组(N)和低氧组(H)。实验前 SHR 尾动脉压(25.4±2.6kPa,n=20)明显高于WKY(13.1±1.6kPa,n=20),P<0.001。SHR-N组血浆心钠素(ANP)、血管紧张素Ⅱ(AⅡ)含量和肾素活性(RA)明显高于WKY-N。SHR-N经实验两周后血压自然上升(P<0.01)。SHR和WKY缺氧后ANP、AⅡ、RA各值均比各自对照值增加,但血压无明显改变.而肺动脉压均明显升高。以上结果提示,SHR 大鼠慢性缺氧后,ANP和肾素-血管紧张素系统可能对防止血压上升和限制肺动脉高压进一步发展起一定的调节作用。
Spontaneously hypertensive rat (SHR) and Wistar-Kyoto rat (WKY) of same age were divided into normoxic group (N) and hypoxic group (H). The caudal arterial blood pressure of SHR (25.4±2.6kPa, n = 20) was significantly higher than that of WKY(13.1±1.6kPa, n = 20, P<0.001) prior to altitude treatment. The plasma ANP (atrial natriuretic peptide), AII and RA contents (1319.61 271.0pg/ml, 715.0±65.4pg/ml, 18.3±2.7ng/ml respectively) of SHR-N were obviously greater than those of WKY-N(488.2± 46, 490.7±43.3, 15.8±2.6 respectively). The caudal arterial blood pressure of SHR-N increased spontaneously after 2 weeks (P<0.01). After hypoxic exposure for 15 days plasma ANP, AⅡand RA of both SHR and WKY rats elevated markedly, but their blood pressure showed no change. The pulmonary arterial pressure of both SHR-H and WKY-H significantly increased. The results suggest that during chronic hypoxia ANP and RAS may play important role in the maintenance of systemic blood pressure and limit the further development of pulmonary hypertension in SHR.
出处
《中国应用生理学杂志》
CAS
CSCD
1992年第2期116-119,共4页
Chinese Journal of Applied Physiology
关键词
ANP
RAS
高血压
血液动力学
spontaneously hypertensive rat
hypoxia
ANP
renin-angiotensin
hemodynamics
