摘要
目的探讨血压对Ⅱ型糖尿病患者尿白蛋白排泄的影响。方法同时测定５５４例Ⅱ型糖尿病患者血压和２４ｈ尿白蛋白排泄，根据糖尿病病程、血压和尿白蛋白排泄进行分组评价。结果①伴高血压患者总白蛋白尿（微量＋大量白蛋白尿）和大量白蛋白尿的发生率显著升高（Ｐ＜００５或００１）；②与正常白蛋白尿患者相比，微量和大量白蛋白尿患者高血压发生率明显升高（Ｐ＜００１）。结论高血压明显加速糖尿病患者肾脏病的发生，长期血压正常或正常低值对糖尿病肾病的发生有一定的保护作用。
Objective To investigate the effect of blood pressure on urinary albumin excretion in patients with type Ⅱ diabetes mellitus. Methods Blood pressure and 24 h urinary albumin excretion were measured in 554 patients with type Ⅱ diabetes mellitus, and patients were analysed according to their disease course、 blood pressure and urinary albumin excretion. Results ① Compared with patients who had normal blood pressure, prevalence rates of total albuminuria (microalbuminuria+macroalbuminuria) and macroalbnuria increased significantly in hypertensive diabetics among disease course less than 10 years (Group A), 10～20 years (Group B) and more than 20 years(Group C), ( P< 0 05 or 0 01); ②In comparison with patients with normoalbuminuira, prevalence rates of hypertension raised markedly in diabetics with micro and macroalbuminuria among group A, group B and group C ( P< 0 01). Conclusion Hypertension can accelerate development and progression of diabetic kidney disease, long term normal or lower blood pressure can somewhat contribute to the protection of diabetic nephropathy.
出处
《安徽医科大学学报》
CAS
1999年第3期194-196,共3页
Acta Universitatis Medicinalis Anhui
基金
安徽省卫生厅资助
关键词
糖尿病
II型
白蛋白尿
血压
影响因素
diabetes mellitus,non insulin dependent
albuminuria
blood pressure
