摘要
目的探讨尿转铁蛋白（Ｔｒａｎｓｆｅｒｉｎ）对妊高征肾损害的诊断价值。方法采用速率散射比浊法，对８２例正常妊娠妇女及８７例妊高征患者测定了随意尿转铁蛋白（Ｔｆ）与肌酐（Ｃｒ）比值，并与白蛋白（Ａｌｂ）、Ｎ－乙酰－β－Ｄ葡萄糖苷酶（ＮＡＧ）比较。结果轻度妊高征组患者尿Ｔｆ显著高于正常妊娠组（Ｐ＜００５），中、重度妊高征患者Ｔｆ、Ａｌｂ、ＮＡＧ均较轻度妊高征组及正常妊娠组显著升高（Ｐ＜００１，Ｐ＜００５）。且病情越重，升高越显著。尿Ｔｆ与Ａｌｂ呈显著正相关（ｒ＝０８６３，Ｐ＜０００１），与ＮＡＧ呈显著正相关（ｒ＝０４８１，Ｐ＜００１）。妊高征组尿Ｔｆ均值较正常妊娠组升高约３倍，Ａｌｂ、ＮＡＧ升高约１倍。结论尿Ｔｆ是反映妊高征肾损害敏感的指标，且较Ａｌｂ、ＮＡＧ灵敏。
Objective\ To study the diagnostic value of urinary transferrin measurement on renopathy of pregnancy induced hypertension(PIH).Methods\ The concentration of urinary transferrin(Tf)and albumin (Alb) were measured by immunosassay,N-acetyl-β-D-glucosaminidase(NAG)by enzymatic method in 82 normal pregnant women and 87 patients with PIH.Results\ The level of Tf in mild PIH were significantly higher than that in normal pregnant women( P <0 05).The level of Tf,Alb,NAG in moderate and severe PIH patients were significantly higher than that in mild PIH patients and normal pregnant women( P <0 01, P <0 05)and they increased with the severity of disease.There were positive correlations between Tf and Alb( r =0 863, P <0 001)and Tf and NAG(r=0 481, P <0 01).the mean of Tf in PIH was 3 times higher,while A1b and HAG were 1 time higher than that in normal pregnant women.Conclusion\ Urinary Tf measurement provided a more sensitive indicator to the diagnosis of renopathy of PIH.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1999年第8期475-476,共2页
Chinese Journal of Practical Gynecology and Obstetrics
