摘要
目的探讨脑梗死急性期风痰瘀阻证患者中医证候要素与神经功能缺损程度评分(NDS)及凝血象的相关性。方法选择123例脑梗死急性期,中医证名诊断属风痰瘀阻证患者。按《中风病辨证诊断标准》进行证候评分,参照美国国立卫生研究院卒中量表(NIHSS)进行神经功能缺损评分,同时检测凝血因子凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)含量。研究中医证候与NDS及凝血因子的相关性。结果 123例急性脑梗死风痰瘀阻证患者风证、痰证与NDS评分均呈正相关(r分别为0.2 0 2、0.2 8 5,P分别为0.0 0 2、0.0 0 0);痰证、血瘀证与APTT均呈负相关(r分别为-0.2 1 2-、0.1 8 4,P分别为0.0 0 4、0.031);余证候与NDS及凝血象均无明显相关性。结论脑梗死急性期风痰瘀阻证患者以风证、痰证对患者神经功能缺损影响较大。痰证、瘀证与患者凝血功能密切相关,其分值可反映患者的凝血功能状态。
Objective To investigate the relationship between Chinese medicine syndrome,neurologic function deficit score（NDS）,and coagulation state in acute cerebral infarction with wind phlegm stasis syndrome.Methods One hundred and twenty-three patients（pts） with acute cerebral infarction and wind phlegm stasis diagnosed by Chinese medicine were enrolled.The symptom score was decided according to Diagnostic Criteria for Stroke Differentiating Syndrome.The NDS was scored according to Stroke Scale of the National Institutes of Health（NIHSS）.The prothrombin time（PT）,activated partial thromboplastin time（APTT） and fibrinogen（FIB） were detected.The correlation of Chinese medicine syndrome,NDS and coagulation state were investigated.Results The wind syndrome and phlegm syndrome were positively related to NDS（r1=0.202,P1=0.002,r2=0.285,P2=0.000）.The phlegm syndrome and blood stasis syndrome were negatively related to APTT（r1=-0.212,P1=0.004,r2=-0.184,P2=0.031）.No relationship was found between the other syndrome,NDS and coagulogram.Conclusion In acute cerebral infarction patients with wind phlegm stasis syndrome,the neurologic function deficiency was more likely influenced by wind syndrome and phlegm syndrome.Phlegm syndrome and stasis syndrome were correlated with clotting function,and their scores might reflect the clotting functional status.
出处
《中西医结合心脑血管病杂志》
2011年第4期427-428,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
