摘要
对严重原发性高血压患者进行血流动力学监测,发现有两种类型:一类为高动力型,占多数,一类为非高动力型。Nifedipine对此两类型高血压均有良好的降压效果,并可使异常增高的心排血量下降;加用Captopril后效益增强,副作用减少,提示联合用药的合理性及优越性。通过观察Nifedjpine与Captopril的血流动力学作用,对高动力型高血病症的发病机理作了初步探讨。
Two types of severe primary hypertension have been found through hemodynamic monitoring in patients with severe hypertension, Most of them are of hyperkinetic type while others are of non-hyperkinetic type. Calcium antagonist Nifedipine shows effective for lowering the blood pressure in both types. It also brings about a decrease in abnormally elevated cardiac output. Captopril, angiotensin converting-enzyme inhibitor, may be used as a synergist and it minimizes the side-effects. The superiority and reasonableness of the combined therapy is revealed. Observing the hemodynamies of Nifedipine and Captopril, from the pathogenic mechanism of the hyperkinetic hypertension, a primary conclusion may be drawn. The difference between the two types of hypertension is related to plasma renin activity and the level of catecholamine, however, further study should be necessary.
出处
《铁道医学》
1990年第3期139-141,共3页
Railway Medical Journal
