摘要
目的：探讨乳腺良、恶性病变与ＰＣＮＡ、ｐ５３ 之间的关系及其在临床中的应用价值。方法：６０ 例乳腺癌原发灶，１６ 例乳腺增殖症及９ 例乳腺癌旁异型小叶蜡块采用ＬＳＡＢ 法标记ＰＣＮＡ、ｐ５３ 。结果：ＰＣＮＡ、ｐ５３ 阳性率在三种病变中有非常显著性差异。当ＰＣＮＡ 表达强度为（ ＋ ＋ ～＋ ＋ ＋ ） 时，其阳性率与乳腺癌病理分级、淋巴结有否转移及转移数目呈正相关。ｐ５３ 的表达与组织分化、淋巴结转移情况无明显关系。结论：ＰＣＮＡ 是瘤细胞增生活跃的指标，是判断乳腺癌预后的有效标记物。ｐ５３ 蛋白表达是乳腺癌发生的始动因素之一， 是判断乳腺良、恶性病变的参考指标，但不适合作为乳腺癌理想的预后标记物。
Objective: To study the expressions of PCNA, p53 in breast diseases and their clinical application. Methods: The expressions of PCNA, p53 were determined by LSAB method in paraffin section of 60 cases of primary breast cancer and 16 cases of breast proliferative disease and 9 sections of irregular lobules adjacent to the tumor. Results: Significant difference of positive rates of PCNA and p53 among these three breast entities were observed. The high expression of PCNA (++～+++) was positively correlated with the pathological grade, metastatic state and number of lymph node of breast cancer, but the expression of p53 was not. Conclusion: PCNA is predictive of actively proliferating tumor cells and a good prognostic factor of breast cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第10期750-752,共3页
Chinese Journal of Clinical Oncology
基金
煤炭部科研基金
