摘要
目的 探讨重症肌无力（ＭＧ）患者中枢神经系统损害与白细胞介素（ＩＬ）１ 之间的关系。方法 将ＭＧ患者血中提取的ＩｇＧ注入大鼠脑室系统，建立大鼠中枢神经系统受损模型，然后观察模型大鼠脑、胸腺、血清ＩＬ１ 水平的变化。结果 脑室内注入ＩｇＧ后第１ 周起，脑、胸腺及血清中ＩＬ１ 水平升高，其中脑组织上升最为明显，第２ 周末达高峰；而在胸腺及血中上升则相对缓慢，第３ 周末时仍在缓慢上升。结论 大鼠中枢神经系统受损ＭＧ 模型脑、胸腺及血中ＩＬ１ 水平显著升高，表明其在ＭＧ患者中枢神经系统损害过程中可能起重要作用。
Objective Recent studies have demonstrated that acetylcholine receptor antibodies (AChRab) present in the serum of the patients with myasthenia gravis (MG) not only block acetylcholine transmission at the neuromuscular junction, but also cause dysfunction of central nervous system (CNS). The mechanism remains unclear. In the present study the concentration of interleukin 1 in the brain, thymus and blood was investigated to reveal the mechanism of CNS dysfunction in MG. Methods The concentration of interleukin 1 in brain, thymus and blood was detected after establishing the experimental MG model of central nervous system dysfunction induced by injection of AChRab purified from MG sera into the rat cerebral ventricular system. Results Interleukin 1 level in brain, thymus and blood started to increase one week after injection of AChRab. The level of interleukin 1 in brain tissue showed a very significant increase, as compared to that in thymus and blood till the end of 2 weeks after injection, where as in thymus and blood the increasing rate was relatively slow. Conclusion It is concluded that interleulin 1 increased in rat brain, thymus and blood may play an important role in generating dysfunction of CNS in MG.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第10期660-662,共3页
Chinese Journal of Internal Medicine
基金
国家自然科学基金!( 编号:39670264)
