摘要
目的:探讨血瘀证目征与血管内皮细胞损伤的关系。方法:将54只新西兰大白兔按随机分组法分为6组,分别为气虚血瘀组、气滞血瘀组、寒凝血瘀组、热毒血瘀组、外伤血瘀组、正常对照组。比较各组血瘀证目征积分,同时观测各组血清中vWF、ET-1水平的变化。结果:造模前各组血瘀证目征积分无显著差异:造模后各治疗组与对照组相比均有极显著差异(P<0.01):经补阳还王汤等中药2周治疗后,各治疗组与各自造模后相比均有极显著差异(P<0.01)。造模前各组血清ET-1,vWF的水平无显著差异,造模后血清ET-1,vWF水平各治疗组与对照组相比均有极显著差异(P<0.01),治疗后,各治疗组与各自造模后相比均有极显著差异(P<0.01)。结论:血瘀证目征是诊断血瘀证的有效方法,血瘀证目征与血管内皮细胞损伤有密切相关。
Objective：To investigation the relationship between the eye signs of blood stasis syndrome and the vascular endothelial cell injury.Methods：In this study a sample of 54 rabbits randomly divided into 6 blood stasis groups：qi deficiency group,qi stagnation group,cold coagulation group,heat-toxicity group,trauma group and normal control group.Comparison of the Eye Signs scores of blood stasis syndrome in each group,while observing the changes of vWF,ET-1 levels in serum.Results：There was no significant difference on eye signs scores in each group before modeling;After modeling,the scores of eye signs in all treatment groups compared with the control group were significantly different（P0.01）;After treatment,the eye signs scores of each treatment group were significantly different when compared with themselves just after modeling（P0.01）.Before modeling the serum ET-1,vWF levels were no significant differences in each group;After modeling,serum ET-1,vWF levels in all treatment groups compared with the control group were significantly different（P0.01）：After treatment,the serum ET-1,vWF levels of each treatment group were significantly different when compared with themselves just after modeling（P0.01）.Conclusion：Eye signs of blood stasis syndrome are effective diagnostic method,eye signs and vascular endothelial cell injury are closely related.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2011年第4期781-784,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金(No.30960473/C190106)~~
