摘要
目的研究华北耧斗菜(Aquilegia yabeana Kitag)中的化学成分。方法利用Diaion HP-20、Toyopearl HW-40、硅胶柱等柱色谱技术进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果分离并鉴定了13化合物的结构,分别为:3,4-二羟基苯乙酸(Ⅰ),羟基酪醇(Ⅱ),邻苯二酚(Ⅲ),对羟基苯乙醇(Ⅳ),3-甲氧基-4-羟基苯乙醇(Ⅴ),原儿茶酸(Ⅵ),没食子酸(Ⅶ),5,7,4′-三羟基-8-C-β-D-葡萄糖黄酮碳苷(Ⅷ),5,4′-二羟基-6,7-二甲氧基-8-C-β-D-葡萄糖黄酮碳苷(Ⅸ),5,7,4′-三羟基-6-甲氧基-8-C-β-D-葡萄糖黄酮碳苷(Ⅹ),5,7,8,4′-四羟基-6-C-β-D-葡萄糖黄酮碳苷(Ⅺ),槲皮素-3-O-β-D-木糖-(1→2)-β-D-半乳糖苷(Ⅻ),芦丁(ⅩⅢ)。结论以上13个化合物均为首次从本植物中分离得到。
OBJECTIVE To study the chemical constituents of Aquilegia yabeana Kita.METHODS The compounds were isolated by Diaion HP-20,Toyopearl HW-40,and silical gel column chromatography.The structures of these compounds were identified by physiochemical properties and spectral analysis.RESULTS Thirteen compounds were obtained,and their structures were identified as 3,4-dihydroxyphenyl acetic acid（Ⅰ）,hydroxytyrosol（Ⅱ）,pyrocatechol（Ⅲ）,4-hydroxyphenethyl alcohol（Ⅳ）,4-hydroxy-3-methoxyphenylethanol（Ⅴ）,protocatechuic acid（Ⅵ）,gallic acid（Ⅶ）,8-β-D-galactopyranosyl-5,7,4′-trihydroxyflavone（Ⅷ）,5,4′-dihydroxy-6,7-dimethoxy-8-C-β-D-glucopyranosylflavone（Ⅸ）,5,7,4′-trihydroxy-6-methoxy-8-C-β-D-glucopyranosyl flavone（Ⅹ）,6-β-D-galactopyranosyl-5,7,8,4′-tetrahydroxyflavone（Ⅺ）,quercetin-3-O-β-D-xylopyranosyl-（1→2）-β-D-galactopyranoside（Ⅻ）,and rutin（ⅩⅢ）.CONCLUSION All the compounds were isolated from this plant for the first time.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2011年第7期496-499,共4页
Chinese Pharmaceutical Journal
基金
教育部科学技术研究重点项目(DF2003078)
关键词
华北耧斗菜
3
4-二羟基苯乙酸
没食子酸
黄酮
化学成分
Aquilegia yabeana Kitag
3
4-dihydroxyphenyl acetic acid
gallic acid
flavone
chemical constituents
