期刊文献+

表观遗传学在抗肿瘤领域的研究现状及前景

在线阅读 下载PDF
导出
摘要 表观遗传学主要通过基因水平调控表观形状,从而产生多种多样的表型性状,本文主要通过表观遗传学的四个机制出发,探讨表观遗传学在现代抗肿瘤领域中的重要作用,提出了一些表观遗传学所改变的特征,综述了表观遗传学发展状况并展望了表观遗传学的未来前景。
作者 赵纭正
出处 《吉林农业(学术版)》 2011年第3期69-69,共1页
  • 相关文献

参考文献7

  • 1尤程程,黄利鸣.DNA甲基化与肿瘤[J].广东医学,2009,30(8):1201-1203. 被引量:2
  • 2孙树汉.肿瘤的表观遗传学研究[J].中国肿瘤生物治疗杂志,2008,15(1):8-13. 被引量:22
  • 3刘鹏,王一理,司履生.组蛋白乙酰化及其与肿瘤的关系[J].中华病理学杂志,2002,31(3):263-265. 被引量:4
  • 4Widschwendter A,Muller HM,Fiegl H,et al.DNA methylation in serum and tumors of cervical cancer patients. Clinical Cancer Research . 2004
  • 5MasieroM,NardoG,lndraccoloS,etal.RNA interference:implications for cancer treatment. Molecular Aspects of Medicine . 2007
  • 6C Stresemann,B Brueckner,T Musch,H Stopper,F Lyko.Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Research . 2006
  • 7Chen W,Cooper TK,Zahnow CA,Overholtzer M,Zhao Z,Ladanyi M,Karp JE,Gokgoz N,Wunder JS,Andrulis IL,LJvine AF,Mankowski JL,Baylin SB.Epigenetic and genetic loss of Hic1function accentuates the role of p53in tumori-genesis. Cancer Cell . 2004

二级参考文献65

  • 1KAZUAKI M, TOSHIKAZU U. Diagnostic and Therapeutic Applications of Epigenetics[ J ]. Jpn J Clin Oncol, 2005, 35 (6) : 293 - 301.
  • 2DAS P M, SINGAL R. DNA methylation and cancer[J].J Clin Oncol, 2004, 22 ( 22 ) : 4 632 - 4 642.
  • 3MEHROTRA J, VALI M, MCVEIGH M, et al. Very high frequency of hypermethylated genes in breast cancer metastasis to the bone, brain, and lung [J]. Clin Cancer Res, 2004, 10 (9) : 3 104-3 109.
  • 4LONG N K, KATO K, YAMASHITA T, et al. Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas[J]. Oral Oncol, 2008, 44( 11 ) : 1 052 - 1 058.
  • 5ELLINGER J, EL KASSEM N, HEUKAMP L C, et al. Hypermethylation of Cel - Free Serum DNA Indicates Worse Outcome in Patients With Bladder Cancer[J]. J Urol, 200g, 179(1): 346-352.
  • 6SAWADA M, KANAI Y, ARAI E, et al. Increased expression of DNA methyltransferase 1 (DNMTI) protein in uterine cervix squamous cell carcinoma and its precursor lesion [ J ]. Cancer Lett, 2007 , 251(2): 211 -219.
  • 7DING W J, FANG J Y, CHEN X Y, et al. The expression and clinical significance of DNA methyhransferase proteins in human gastric cancer[J]. Dig Dis Sci, 2008, 53(8) : 2 083 -2 089.
  • 8KANTARJIAN H, OKI Y, GARCIA - MANERO G, et al. Resuits of a randomized study of 3 schedules of low - dose decitabine in higher - risk myelodysplastic syndrome and chronic myelomonocytic leukemia[J].Blood. 2007. 109( 1 ) : 52 -57.
  • 9CHENG J C, WEISENBERGER D J, GONZALES F A, et al. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells [ J 1. Mol Cell Biol, 2004, 24 (3) : 1 270-1 278.
  • 10HERMAN J G, BAYLIN S B. Gene silencing in cancer in association with promoter hypermethylation [ J ]. N Engl J Me, 2003, 349 (21) : 2 042 -2 054.

共引文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部