摘要
体细胞核移植技术因低效和后代生长发育异常等缺陷而未能广泛应用,关键在于对体细胞核移植的表观遗传的机制缺乏了解。供体细胞核的不完全重编程被认为是造成克隆胚胎不能正常发育到成年的首要原因。深入探讨体细胞核移植动物中潜在的表现遗传修饰机制,将有助于了解体细胞核移植动物能够正常发育的后成重编程机理。
Application of somatic cell nuclear transfer （SCNT） is limited due to various reasons, especially, low efficacy and birth defect cloned offspring, and this is because that the epigenetic mechanism underlying somatic cell nuclear transfer is not well known yet. Incomplete epigenetic reprogramming is suspected to cause the abnormalities and the low efficacy associated with SCNT, To elucidate the epigenetic reprogramming threshold for proper development will surly be helpful to understanding the molecular mechanisms underlying SCNT animals surviving to adulthood.
出处
《中国比较医学杂志》
CAS
2008年第8期49-52,共4页
Chinese Journal of Comparative Medicine
关键词
核移植
表观遗传
Nuclear transfer
Epigenetics
