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青年乳腺癌临床病理特点及预后分析 被引量:10

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摘要 目的探讨青年女性乳腺癌的临床病理特点及年龄对预后的影响。方法按年龄将407例女性乳腺癌患者分为青年组(≤35岁)和对照组(>35岁),对比分析两组的临床病理特点,包括TNM分期、病理类型、肿瘤大小、淋巴结转移情况、雌激素受体(ER)表达、孕激素受体(PR)表达、人表皮生长因子受体2(c-erbB-2)表达和p53表达,并对全部患者进行随访,用Kaplan-Meier方法绘制生存曲线,Log-Rank检验比较组间无病生存(DFS)率的差异。结果青年组、对照组c-erBb-2阴性表达率分别为77.8%和59.0%(P=0.028);3 a DFS率分别为84.9%和92.4%(P=0.010);青年组ER、PR阴性表达率高,p53阳性率高,淋巴结易转移,但无统计学差异(P>0.05);两组间TNM分期、病理类型、肿瘤大小、手术方式、术后是否接受辅助放化疗及内分泌治疗等均无差异。结论青年乳腺癌复发转移出现早,预后差。
出处 《山东医药》 CAS 北大核心 2011年第12期81-82,共2页 Shandong Medical Journal
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