摘要
目的：探讨影响肾病综合征（ｎｅｐｈｒｏｔｉｃｓｙｎｄｒｏｍｅ，ＮＳ）患者脂蛋白（ａ）［ｌｉｐｏｐｒｏｔｅｉｎａ，ＬＰ（ａ）］水平的因素，并比较不同病理类型ＮＳ的ＬＰ（ａ）。方法：分析５７例原发性ＮＳ和６５例肾炎患者的临床和病理资料。结果：ＮＳ患者的ＬＰ（ａ）为（７４３±５３７）ｍｇ·Ｌ－１，较对照组（２０８±１６１）ｍｇ·Ｌ－１明显升高（Ｐ＜０．００１）；１０例ＮＳ患者在缓解后ＬＰ（ａ）水平明显下降。ＮＳ组患者的ＬＰ（ａ）与总胆固醇、低密度脂蛋白、载脂蛋白Ｂ正相关（ｒ＝０．３８，０．４３，０．３３，Ｐ＜０．００１），与血浆白蛋白浓度负相关（ｒ＝－０．３４，Ｐ＜０．００１）。在原发性肾病综合征中，轻度系膜增生性肾炎或ＩｇＡ肾病患者的ＬＰ（ａ）（９４２±６９０）ｍｇ·Ｌ－１较膜性肾病患者的ＬＰ（ａ）（５６６±３１１）ｍｇ·Ｌ－１明显升高（Ｐ＜０．０５）。结论：肾病综合征患者血ＬＰ（ａ）明显升高的主要原因是合成增加，ＬＰ（ａ）不仅被动升高，可能也是加重肾小球损伤的因素之一。
Objective: To investigate the factors that influence the level of lipoprotein(a) and relationship between the level of lipoprotein(a) and renal pathology type in primary nephrotic syndrome (NS) patients. Methods: The clinical and pathological data of 57 primary NS patients and 65 mild mesangial proliferative glomerulonephritis(MGN) patients were analyzed. Results: LP(a) was significantly elevated in NS group than in control group [(743±537 vs 208±161) mg·L -1 , P < 0.001 ], and decreased after remission. LP(a) correlated positively with TC, LDL C, ApoB( r = 0.38 , 0.43 , 0.33, P <0.001), and negatively with plasma albumin ( r =-0.34, P <0.001)in NS group. Lp(a) was higher in MGN group than in membranous nephropathy group [(942±690 vs 566±311) mg·L -1 , P <0.05]. Conclusion: Elevated LP(a) in NS was due to increased synthesis, and might also accelerate glomerular injury.
出处
《北京医科大学学报》
CSCD
1999年第4期373-375,共3页
Journal of Peking University(Health Sciences)
关键词
肾病综合征
病理学
血液
脂蛋白(Α)
Nephrotic syndrome/pathol Glomerulonephritis, membranoproliferative/pathol Lipoprotein(a)/blood
