摘要
对４５例原发性肾病综合征（ＮＳ）患者的血脂和载脂蛋白（ａｐｏ）进行检测，发现ＮＳ患者具有广泛的脂代谢异常，ａｐｏＡＩ（ｌｌｌ２±ｌ８７ｍｇ／Ｌ）、ＡＩＩ（２６６±７７ｍｇ／Ｌ）浓度降低，ａｐｏＢｆ１７ｌ０±４４４ｍｇ／Ｌ）、ＣＩＩ（９７±４２ｍｇ／Ｌ）、ＣＩＩＩ（２４７±９６ｍｇ／Ｌ）浓度显著升高，ａｐｏＡｌ／ａｐｏＢ比值（０．７０±０．２４）显著降低。而在缓解期，一部分患者血脂、脂蛋白浓度正常，但ａｐｏ仍有明显异常。结果提示：ＮＳ患者发生冠心病的危险性增加，而ａｐｏ是较血脂更为敏感的ＮＳ心血管并发症的预测指标。
e measured serum lipid and
apolipoprotein(apo) levels in 45 patients with noimal renal functionat different stages of
idiopathic nephrotic syndrome(NS). Wide abnonnalities of lipid metabolism werefound. The
characteristic disorder of serum apos in NSwas a decrease in apoAl and AII and a significant
in-crease in apoB, CII, and CIII. Consequently, the ratioof apoAI to apoB was significantly
decreased. Somepatients with NS in remission had nonnal serum lipidconeentrations, but
abnonnalities of serum apos werestill observed. It is suggested that the nephrotic pa-tients may
be at increasing risk for coronary heart disease (CHD), and that apos may be more
sensitivepredicators of CHD than lipids.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1994年第9期542-544,共3页
National Medical Journal of China
关键词
高血脂病
肾病综合征
载脂蛋白
Nephrotic syndrome Apoli-poproteins
Hy[)erlipidemia
