摘要
目的：探讨砷对小鼠及人体 Ｓ Ｏ Ｄ活力的影响。方法：给予小鼠灌胃染毒亚砷酸钠，观察小鼠全血及组织中 Ｓ Ｏ Ｄ活力的变化，同时对接砷人群全血中 Ｓ Ｏ Ｄ活力进行检测。结果：在急性实验中，全血及心脏中 Ｓ Ｏ Ｄ 活力中、高剂量组显著降低；肝脏低剂量组、肾脏中剂量组 Ｓ Ｏ Ｄ活力显著增高，高剂量组则显著降低。亚慢性实验中，低剂量组开始肝脏中 Ｓ Ｏ Ｄ 活力逐渐降低；全血及心脏中 Ｓ Ｏ Ｄ活力仅在高剂量组开始显著降低。人群调查可见病区病人组的 Ｓ Ｏ Ｄ 活力明显低于对照组。结论：砷可引起机体 Ｓ Ｏ Ｄ 活力发生变化，其影响主要表现为抑制作用。
Objective:This papar was to explore the influence of arsenic on the activity of Superoxide dismutase(SOD) in mice and human. Methods:We detected the activity of SOD in blood and tissues of mice by orally administering sodium arsenite in acute and subchronic experiments. The activity of SOD in human blood was measured by epidemiological survey. Results:In acute experiment: activity of SOD in blood and heart decreased sigificantly in moderate and high dosage groups; the activity of SOD increased markedly in hepatic low dosage group as well as renal moderate dosage group and decreased strinkingly in high dosage group. In subchronic experiment: SOD activity in liver began to decrease from low dosage group; the activity in blood and heart began to decrease only in high dosage group. The activity of SOD decreased significantly in patients from diseased area. Conclusion:Arsenic exerted impact on SOD activity in organisms mainly through its inhibitory effect. Conclusion:Arsenic exerted impact on SOD activity in organisms mainly through its inhibitory effect. Arsenic exerted impact on SOD activity in organisms mainly through its inhibitory effect.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1999年第4期269-270,275,共3页
Journal of China Medical University
