摘要
目的观察强噪声暴露对大鼠急慢性胃粘膜损伤的影响。方法急性实验用Ｗｉｓｔａｒ大鼠２０只，随机分为两组，每组１０只。实验组每天给连续６小时强噪声刺激，对照组无噪声刺激；３天后均经口灌注０．８ｍｏｌ／Ｌ盐酸１ｍｌ，观察胃粘膜损伤变化。慢性实验选Ｗｉｓｔａｒ大鼠３６只，均制作胃溃疡模型，实验组１８只，术后给强噪声刺激每天６小时，对照组１８只无噪声刺激；观察两组实验第１０天和第４０天时的大鼠胃溃疡面积。结果经强噪声暴露再灌注盐酸后大鼠胃粘膜损伤指数为１８２．８０±６１．３２，较对照组的６９４．７０±１８３．０２有非常显著性差异（Ｐ＜０．０００１）。慢性胃溃疡模型术后给强噪声暴露第１０天和第４０天的大鼠溃疡面积各与其对照组比较明显为大，均有显著性差异（Ｐ＜０．０５）。
Objevtive To explore the effects of exposure to intense noise on acute injury of gastric mucosa and healing of chronic gastric ulcer in rats.Methods 20 Wistar rats were randomly devided into two equal groups. The experiment group was exposured to intense noise for 6 hours every day and the control group was without noise exposure. After three days, rats of the two groups were perfused with 0.8 mol/l HCl 1 ml p.o. to observe the injury of gastric mucosa. Gastric ulcer models were made in another 36 Wistar rats, and 18 rats of the experiment group were given intense noise exposure after the operation for 6 hours every day, while another 18 rats of the control group were without the noise exposure. Rats of the two groups were killed at the tenth and the fortieth day to observe the area of gastric ulcer.Results The injury index of gastric mucosa was 182.80±61 32 in rats perfused with hydrochloric acid after 3 d exposure to intense noise in contrast to 694 70±183 02 of its control group( P <0 0001). Gastric ulcer areas were (15 33±7 26)mm 2 and (15 11±12 45)mm 2 with intense noise exposure after operation for 10 days and 40 days respectively; and they were significantly larger than those of the corresponding control groups ( P <0 05).Conclusions Intense noise exposure has marked negative influence on acute and chronic injuries of gastric mucosa in rats.
关键词
噪声
胃粘膜损伤
胃溃疡
Noise Gastric mucosa,injury Gastric ulcer
