摘要
目的观察重型闭合性颅脑损伤高压氧（ＨＢＯ）治疗前中后血清脂质过氧化物（ＬＰＯ）代谢产物丙二醛（ＭＤＡ）和超氧化物歧化酶－１（ＳＯＤ－１）的浓度变化。方法５０名患者分为高压氧＋常规治疗组（ＨＢＯ组）３２例和单纯常规治疗组（对照组）１８例，另有３０名健康志愿者作为正常组：于治疗前中后用硫代巴比妥酸比色法检测ＭＤＡ、用放射免疫法检测ＳＯＤ－１。结果ＨＢＯ组和对照组在治疗前的ＭＤＡ（５．２７±１．５９）μｍｏｌ／Ｌ，（５．７１±１．３４）μｍｏｌ／Ｌ和ＳＯＤ－１（２７１．３±１０２．９）μｇ／Ｌ，（２５６．３±１１２．４）μｇ／Ｌ，差异均无显著性（Ｐ＞０．０５），但与正常组比较差异均有非常显著性（Ｐ＜０．０１）；ＭＤＡ和ＳＯＤ－１呈负相关；治疗后ＭＤＡ升高和ＳＯＤ－１明显降低者疗效和预后差。ＨＢＯ组ＭＤＡ降低，为（４．１１±０．３５）μｍｏｌ／Ｌ；ＳＯＤ－１升高，为（３８０．５±１１５．３）μｇ／Ｌ及疗效均较对照组显著。结论ＭＤＡ和ＳＯＤ－１与损伤严重程度有关，可用于判断ＨＢＯ的疗效和预后，并有可能作为调整ＨＢＯ治疗方案的依据。
Objective To observe the changes of malon dialdehyde(MDA) and superoxide dismutase(SOD-1) metabolized from lipid peroxides(LPO) in serum of the patients with severely closed head injury at pre-, mid- and post-treatment of hyperbaric oxygenation(HBO).Methods Fifty patients were divided into two groups randomly.One was treated with HBO combined with conventional treatment(HBO group).The other was only treated with conventional treatment(control group).There were 30 healthy volunteers as the health group.Concentrations of MDA and SOD-1 were measured with spectrometry and radioimmunoassay respectively during the study.Results Before the treatment,the MDA of HBO and control group was respectively (5.27±1.59)μoml/L and (5.71±1.34)μmol/L; the SOD-1 wes separately (271.3± 102.9)μg/L and (256.3±112.4)μg/L.There wasn't significant difference (P>0.05). These data were compared with the health group, there was a significant difference (P<0.01).But there was a negative correlation between the MDA and SOD-1.After the treatment,the patients who had the enhancement of MAD and decrease of SOD-1 were less effects and bad prognosis.After the HBO treatment, the MDA was decreased to (4.11±0.35)μmol/L,the SOD-1 was raised to (380.5±115.3)μg/L.The effects were higher than the control group.Conclusion The changes of MDA and SOD-1 are related with the severity of brain injury.They can be used to judge the curative effect and the prognosis,and used as the basis of adjusting HBO treatment.
出处
《中华理疗杂志》
1999年第4期198-200,共3页
Chinese Journal of Physical Therapy
关键词
颅脑损伤
高压氧治疗
血清
LPO
SOD
Hyperbaric oxygenation
Brain injuries
Malondialdehyde
Superoxide dismutase
