摘要
目的:总结实体瘤外周血中循环肿瘤细胞(CTC)和转移相关性的研究进展。方法:以"循环肿瘤细胞、实体瘤、转移"为关键词,检索2000-01-2010-10 PubMed、Science Direct、Ovid、Springer、CNKI和维普等数据库的相关文献。纳入标准:关于实体瘤CTC与转移密切相关的分子机制、临床相关性的文献。共纳入分析42篇文献。结果:随着分子生物学和材料技术的发展,越来越多的方法有效地富集和鉴定不同类型实体瘤外周血CTC。细胞基因水平证实CTC具有恶性生物学特性,CTC自身基因和转移相关蛋白谱的表达、肿瘤微环境、免疫系统等因素影响着CTC远处器官转移灶的形成。CTC数目、特定基因、蛋白的表达与治疗疗效、预后等具有相关性。结论:研究CTC参与血液播散转移的机制,为全面、准确地阐明恶性实体瘤转移的机制、个体化的治疗提供新的工具。
OBJECTIVE： To review of the studies the relation- ship between circulating tumor cells （CTC）in peripheral blood of solid tumors and the mechanism of metastasis. METHODS： Keyword： circulating tumor cell （CTC）, solid tumors, metastasis. Retrieval system： PubMed, Ovid, Science Direct, Springer, CNKI, Weipu Data. The time limit： 2000-01--2010-10. The enrolled criteria： about the relationship between CTC in peripheral blood of solid tumors and ：the mechanism of metastasis, its clinical rele- vance. Overall, 42 literatures were cited. RESULTS： As the development of the advanced technique of molecular biology and material, more and more methods can be used to enrich and identify CTC. It is reported that cytogenetic evidence that CTC in patients with carcinoma are malignant. The gene and related metastatic protein profile in CTC, tumor microenvironment, immune system can influence on tumor metastasis. The number of CTC, the expression of specific genes and proteins have a relationship with the effect of treatment and evaluation of prognosis. CONCLUSION： The study of the mechanism of CTC disseminating and metastasis to the organs may fully elucidate the mechanism of metastasis and be used as a new tool for tailored treatment for individual patient.
出处
《中华肿瘤防治杂志》
CAS
2011年第1期74-77,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
江苏省卫生厅基金(H200970)
关键词
乳腺肿瘤
肿瘤循环细胞
肿瘤转移
综述文献
breast neoplasms
neoplasms circulating cells
neoplasm metastasis
review literature
