6Kirk S J, Cooper GG, Hoper M, et al. The prognostic signifycancer of marrow micrometastases in women with early breast cancer[J]. Eur J Surg Oncol, 1990, 16: 481-485.
7Osborne M, Rosen P. Detection and management of bone marrow micrometastases in breast cancer[J]. Oncology, 1994, 8:25-36.
8Sloane JP, Ormerod MG, Neville AM. Potential pathological application of immunocytoehemical methods to the [VAC13] detection of micrometastases [J]. Cancer Res, 1980, 40 (8) 3079 -3082.
9Irene G, Nicolas S, John N, et al. In vivo flow cytometry: A new method for enumerating circulating cancer cells[J]. Cancer Res, 2004,64:5044- 5047.
10Lee GS, Ryu KS, Rha JG, et al. Multiparametric flow cytometric analysis in a breast cancer cell line (MCF-7) [J]. J Obstet Gynaecol Res, 2002, 28(3) : 141- 148.
1Ashworth TR. A case of cancer in which cells similar to those in the tumors were seen in the blood after death[J]. Aust Med J, 1869,14:146.
2Paget S. Distribution of secondary growths in cancer of the breast [J]. Lancet, 1889,1:571.
3Jiang Z F,Cristo fanilli M,Shao Z M,et al. Circulating tumor cells predict progression-free and overall survival in Chinese patients with metastatic breast cancer, HER2-positive or triple-negative (CBCSG004) : a multicenter, double-blind, prospective trial [J]. Ann Oncol,2013.
4von Minekwitz G, Untch M, Blohmer JU, et al. De nition and im- pact of pathologiccomplete response on prognosis after neoadju- vant chemotherapy in variousintrinsie breast cancer subtypes[J]. J Clin Oncol, 2012,30 : 1796.
5Aliki Stathopoulou, Anna Gizi, Maria Perraki, et al. Real-Time Quantification of CK-19 mRNA-Positive Ceils in Peripheral Blood of Breast Cancer Patients Using the Lightcycler System[J]. Clini- cal Cancer Research, 2003,9 : 5145.
6De Giorgi,et al. Circulating Tumor Cells and Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Out- come Prediction in Metastatic Breast Cancer[J]. Clin Oncol, 2009, 27(20) :3303.
7Ramadan A, Harouakal, et al. Circulating Tumor Cell Enrich- ment Based on Physieal Properties[J]. Journal Laboratory Auto- mation,2013,18(6) :455.
8Caitlin D May1, Nathalie Sphyrisl, et al. Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast[J]. J Breast Cancer Research, 2011,13 : 202.
9ousden KH, Lane DP. P53 in health and disease[J]. Nat Rev MolCell Bicol, 2007,8 ( 11 ) : 275.
10Shirley S H,Rundhaug J E,T ian J,et al. T ranscript iona 1 regulation of estrogen recep tor-a by p53 in hum an breast cancer cells[J]. Cancer Res,2009,69(8) :3405.
