摘要
目的:总结目前肺癌表观遗传学的研究进展,指导肺癌的早期诊断、治疗及预后。方法:应用NCBI的Pubmed和CHKD期刊全文数据库检索系统,以"肺癌、表观遗传学"等为关键词,检索2004-01-2009-12相关文献24篇。纳入标准:1)DNA甲基化。2)组蛋白修饰。3)非编码RNA调控,包括RNA干扰及MicroRNA。根据纳入标准分析24篇文献。结果:表观遗传学改变,如DNA的甲基化、组蛋白修饰及非编码RNA调控等在肺癌的发生、发展中起着重要作用,可以指导肺癌的早期诊断、治疗及预后。结论:对肺癌表观遗传学的深入研究,将为肺癌的治疗提供新的策略和方法。
OBJECTVE..To summarize the current articles about the lung cancer epigenetics and guide early diagnosis, treatment and prognosis. METHODS The papers published from 2004-01 to 2009-12 were searched from Pubmed of NCBI and CHKD full-text database index systems with the keywords ＂lung cancer, epigenetics etc. ＂. Totally 584 articles in English and 24 articles in Chinese were reviewed. Choice criteria.. 1）DNA methylation. 2）Histone modification. 3）noncoding RNA regulation, including RNA interference and MicroRNA. According to the choice criteria, 24 papers were finally decided as references. RESULTS： The alterations of epigenetics, such as DNA methylation, histone modification and noncoding RNA regulation play an important role in the occurrence and development of lung cancer, which can guide early diagnosis, treatment and prognosis. CONCLUSION： The intensive study of epigenetics will provides a new strategy and method for the treatment of lung cancer.
出处
《中华肿瘤防治杂志》
CAS
2011年第1期70-73,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
肺肿瘤
遗传学
综述文献
lung neoplasms genetics review literature
